Stem-loop hsa-mir-451a

Accession

MI0001729

Symbol

HGNC: MIR451A

Description

Homo sapiens hsa-mir-451a precursor miRNA mir-451

Gene
family

RF00722; mir-451

Literature search

287 open access papers mention hsa-mir-451a
(1370 sentences)

Sequence

1250750 reads, 3417 reads per million, 125 experiments

cuugggaauggcaaggAAACCGUUACCAUUACUGAGUUuaguaaugguaaugguucucuugcuauacccaga
.(((((.(((((((((.(((((((((((((((((....))))))))))))))))).))))))))).))))).

Structure

c     a         A                 A 
 uuggg auggcaagg AACCGUUACCAUUACUG G
 ||||| ||||||||| |||||||||||||||||  
 gaccc uaucguucu uugguaaugguaaugau U
a     a         c                 U 

Annotation confidence Not enough data

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr17: 28861369-28861440 [-]

Clustered miRNAs

3 other miRNAs are < 10 kb from hsa-mir-451a

Disease association

hsa-mir-451a is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-451a is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-451a is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-451a

• Accession: MIMAT0001631
• Description: Homo sapiens hsa-miR-451a mature miRNA
• Sequence: 17 - AAACCGUUACCAUUACUGAGUU - 38
• Evidence: experimental ; cloned [1-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267