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MIR451A is a functional miRNA expressed in red blood cells (RBCs) that is involved in the regulation of cellular functions [PMC5772623]. It has been shown that MIR451A is transferred from infected RBCs to endothelial cells via extracellular vesicles (EVs) [PMC5772623]. The EVs containing MIR451A form a RNA-induced silencing complex (RISC) with Argonaute-2 [PMC7005784]. The expression of MIR451A in EVs has been found to be altered in various conditions. For example, in exosomes released from glioblastoma neurosphere cells, MIR451A exhibited a significant increase [PMC4598952]. Conversely, in EVs from epithelial ovarian cancer patients, the expression of MIR451A was decreased compared to the control group [PMC8997481]. In colorectal cancer cells, overexpression of MIR451A led to a decrease in the level of linc00467 [PMC7471755]. In addition, hemolysis markers such as miR-23a and MIR451A have been used to assess hemolysis in plasma samples [PMC6683928]. The expression level profile of parent cells, such as RBCs and MIR451A, is mirrored in EVs [PMC6992906]. Furthermore, the levels of MIR451A have been associated with inflammatory responses to influenza A virus vaccines [PMC8087664]. Finally, MYBPC1 has been identified as a target gene regulated by MIR451A through activating transcription factor-2 (ATF-2) and plays an important role in laryngeal carcinoma cellular functions regulation [PMC9760473].