miRBase entry: hsa-mir-433

Stem-loop hsa-mir-433

Homo sapiens hsa-mir-433 precursor miRNA
Gene family
MIPF0000177; mir-433

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR433 is a microRNA that has been studied in various contexts. One study reported that down-regulation of MIR433 is associated with tumor suppression [PMC8235499]. In the brain with multiple system atrophy (MSA), MIR433 with reduced expression in the striatum is involved in the regulation of HDAC6 expression [PMC9025474]. MIR433 has been grouped by tertiles for statistical analysis [PMC3593171]. In a limited cohort of samples, differential signatures have shown upregulation of miR101, miR25, miR26b, miR335, and MIR433 [PMC7959144]. The binding between CREB1 and the MIR433 promoter has been studied using LV5-NC- and LV5-CREB1-infected cells [PMC6326693]. Several microRNAs, including MIR128, miR125, and MIR433, have been shown to regulate NMD factors [PMC6173407]. The expression of MIR433 has been observed in various diseases such as bladder tumor tissues and neurodegenerative diseases like Parkinson's disease and Huntington's disease [PMC4348104] [PMC4794499] [PMC9781427]. In esophageal cancer and glioma, MIR433 plays an important role [PMC9753082]. It has also been implicated in regulating OPN/SPP1 expression in bone tissues during tibial fracture healing [PMC9753082]. The expression of OPN/SPP1 is regulated by microRNAs including MIR433. Additionally, it has been shown that estrogen-related ERRĪ³ receptor may regulate transcription of the MIR433 gene from its locus. Furthermore, urinary excretion profile analysis showed an increase in fibrosis activators such as miR-21 or decrease in fibrosis suppressors like miR-29 or miR-200 in patients with renal fibrosis compared to healthy subjects [PMC6612965].

Literature search
75 open access papers mention hsa-mir-433
(576 sentences)


5947 reads, 81 reads per million, 107 experiments

  gg      gUA   U           U   --------  g     cu 
cc  ggagaa   CGG GAGCCUGUCAU AUU        Ca agagg  a
||  ||||||   ||| ||||||||||| |||        || |||||   
gg  ccucuU   GCU CUCGGGUAGUA UAg        gu ucucc  g
  -a      GUG   C           C   gaagaguu  g     ua 

Annotation confidence High
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Genome context
chr14: 100881886-100881978 [+]
Clustered miRNAs
6 other miRNAs are < 10 kb from hsa-mir-433
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-433 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-433-3p

Accession MIMAT0001627
Description Homo sapiens hsa-miR-433-3p mature miRNA
Evidence experimental
cloned [1-2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-433-5p

Accession MIMAT0026554
Description Homo sapiens hsa-miR-433-5p mature miRNA
Evidence experimental
Illumina [3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45