Accession
MI0001446
Symbol
HGNC:
MIR424
Description
Homo sapiens
hsa-mir-424 precursor miRNA mir-322
Gene
family?
family?
RF00737;
mir-322
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR424, which is the ortholog of rat miR322, is a microRNA involved in the regulation of various cellular processes [PMC7123062]. In the context of tumor growth, a significant reduction in MIR424 expression has been observed in tumors that exceed 5 cm in diameter [PMC8007794]. This decrease in MIR424 levels appears to be temporally associated with the induction of vascular smooth muscle cell (vSMC) proliferation, as its concentration initially drops following this cellular event but subsequently increases [PMC7123062]. The dynamic expression pattern of MIR424 suggests a potential role in tumor progression and cellular proliferation processes [PMC8007794; PMC7123062]..
Literature search
166 open access papers mention hsa-mir-424
(848 sentences)
(848 sentences)
Sequence
735528
reads,
5350
reads per million, 122 experiments
cgaggggauaCAGCAGCAAUUCAUGUUUUGAAguguucuaaaugguuCAAAACGUGAGGCGCUGCUAUacccccucguggggaagguagaaggugggg
(((((((.((.((((((..(((((((((((((.((((...)))).)))))))))))))..)))))).)).))))))).....................
(((((((.((.((((((..(((((((((((((.((((...)))).)))))))))))))..)))))).)).))))))).....................
Structure
--------------------- a C AA g c
cgagggg ua AGCAGC UUCAUGUUUUGAA uguu
||||||| || |||||| ||||||||||||| |||| u
gcucccc aU UCGUCG GAGUGCAAAACuu guaa
gggguggaagauggaaggggu c A CG g a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This hairpin precursor expresses a 5' arm product, named miR-424, in human promyelocytic leukemia (HL-60) cells [1]. The level of expression of miR-424 was shown to be up-regulated 48 hours after TPA-induction. The sequence is orthologous to the experimentally verified rat miR-322 locus (MIR:MI0000589), which expresses its mature product from the 3' arm of the hairpin. The human miR-424 hairpin does not appear to contain the miR-322 sequence.
Genome context
chrX: 134546614-134546711 [-]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-424
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-424 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-424-5p
| Accession | MIMAT0001341 |
| Description | Homo sapiens hsa-miR-424-5p mature miRNA |
| Sequence | 11 - CAGCAGCAAUUCAUGUUUUGAA - 32 |
| Evidence |
experimental
cloned [1-2], Northern [1] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-424-3p
| Accession | MIMAT0004749 |
| Description | Homo sapiens hsa-miR-424-3p mature miRNA |
| Sequence | 48 - CAAAACGUGAGGCGCUGCUAU - 68 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
References
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