Stem-loop hsa-mir-424

Accession

MI0001446

Symbol

HGNC: MIR424

Description

Homo sapiens hsa-mir-424 precursor miRNA mir-322

Gene
family

RF00737; mir-322

Literature search

166 open access papers mention hsa-mir-424
(848 sentences)

Sequence

735507 reads, 3500 reads per million, 122 experiments

cgaggggauaCAGCAGCAAUUCAUGUUUUGAAguguucuaaaugguuCAAAACGUGAGGCGCUGCUAUacccccucguggggaagguagaaggugggg
(((((((.((.((((((..(((((((((((((.((((...)))).)))))))))))))..)))))).)).))))))).....................

Structure

---------------------       a  C      AA             g    c 
                     cgagggg ua AGCAGC  UUCAUGUUUUGAA uguu  
                     ||||||| || ||||||  ||||||||||||| |||| u
                     gcucccc aU UCGUCG  GAGUGCAAAACuu guaa  
gggguggaagauggaaggggu       c  A      CG             g    a 

Annotation confidence High

Comments

This hairpin precursor expresses a 5' arm product, named miR-424, in human promyelocytic leukemia (HL-60) cells [1]. The level of expression of miR-424 was shown to be up-regulated 48 hours after TPA-induction. The sequence is orthologous to the experimentally verified rat miR-322 locus (MIR:MI0000589), which expresses its mature product from the 3' arm of the hairpin. The human miR-424 hairpin does not appear to contain the miR-322 sequence.

Genome context

chrX: 134546614-134546711 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-424

Disease association

hsa-mir-424 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-424-5p

• Accession: MIMAT0001341
• Description: Homo sapiens hsa-miR-424-5p mature miRNA
• Sequence: 11 - CAGCAGCAAUUCAUGUUUUGAA - 32
• Evidence: experimental ; cloned [1-2], Northern [1]

Mature hsa-miR-424-3p

• Accession: MIMAT0004749
• Description: Homo sapiens hsa-miR-424-3p mature miRNA
• Sequence: 48 - CAAAACGUGAGGCGCUGCUAU - 68
• Evidence: experimental ; cloned [2-3]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043