Accession
MI0000825
Symbol
HGNC:
MIR345
Description
Homo sapiens
hsa-mir-345 precursor miRNA mir-345
Gene
family?
family?
RF01044;
mir-345
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR345 is a microRNA implicated in various cancer-related processes, including cell proliferation and invasion, particularly in colorectal cancer, where its expression is down-regulated due to methylation sensitivity [PMC3383700]. It is produced following signal transduction initiated by the binding of SDF1 to CXCR4 in astrocytes [PMC7795138]. In pancreatic cancer tissues, MIR345 is one of the miRNAs found to be differentially expressed, suggesting a potential role for miRNA-based therapies [PMC7457762]. Additionally, MIR345 forms part of circRNA-miRNA-mRNA networks that may be relevant for understanding molecular interactions in cancer [PMC7312917]. Its expression is also reduced in colorectal cancer due to the hypermethylation of its promoter [PMC8910953], and it has been identified as a low-level expressed miRNA in tumor tissues or cells [PMC7797122], as well as being dose-dependently reduced following endothelial injury by oxLDL [PMC9199460]. In network analyses related to gastric cancer survival, MIR345 was identified as one of the significant factors [PMC5856436], and it has been recognized as a metastasis-suppressive gene alongside other protein-coding genes and microRNAs [PMC8484294]. Overexpression of MIR345 has been associated with malignant transformation and increased lesion severity during progression from leukoplakia to invasive oral squamous cell carcinoma (OSCC) [PMC3292026; PMC5596676]..
Literature search
39 open access papers mention hsa-mir-345
(137 sentences)
(137 sentences)
Sequence
30865
reads,
321
reads per million, 125 experiments
acccaaacccuaggucuGCUGACUCCUAGUCCAGGGCUCgugauggcugguggGCCCUGAACGAGGGGUCUGGAGgccuggguuugaauaucgacagc
...(((((((.((((((.(.(((((((.((.((((((((((........)))))))))).)).))))))).).)))))))))))))............
...(((((((.((((((.(.(((((((.((.((((((((((........)))))))))).)).))))))).).)))))))))))))............
Structure
---------acc u G U A C gau
caaaccc aggucu C GACUCCU GU CAGGGCUCgu g
||||||| |||||| | ||||||| || ||||||||||
guuuggg uccgGA G CUGGGGA CA GUCCCGggug g
cgacagcuauaa - G U G A guc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted human homologue [2] of a sequence cloned from rat neuronal tissue [1], later validated in human [3,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chr14: 100307859-100307956 [+]
Disease association
hsa-mir-345 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-345-5p
| Accession | MIMAT0000772 |
| Description | Homo sapiens hsa-miR-345-5p mature miRNA |
| Sequence | 18 - GCUGACUCCUAGUCCAGGGCUC - 39 |
| Evidence |
experimental
cloned [3-4], Northern [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-345-3p
| Accession | MIMAT0022698 |
| Description | Homo sapiens hsa-miR-345-3p mature miRNA |
| Sequence | 54 - GCCCUGAACGAGGGGUCUGGAG - 75 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
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References
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