Accession
MI0000812
Symbol
HGNC:
MIR331
Description
Homo sapiens
hsa-mir-331 precursor miRNA mir-331
Gene
family?
family?
RF00769;
mir-331
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR331 is a microRNA implicated in various biological processes and diseases, including cancer and cardiovascular conditions [PMC5447065]. It is suggested to play a role in chronic lymphocytic leukemia (CLL) by potentially targeting SOCS1, a gene whose reduced expression is associated with cancer cell survival and proliferation [PMC6183594]. MIR331 is also differentially expressed in osteosarcoma (OS), correlating with patient survival rates, and has been identified as one of the m6A-related ncRNAs significantly associated with overall survival [PMC8648947]. In the context of gene expression regulation, MIR331's function can be inhibited by G-quadruplex structures that prevent miRNA binding to its target mRNA [PMC5513062]. Additionally, MIR331 has been linked to high-density lipoprotein cholesterol (HDL-c) levels through genome-wide association studies (GWAS), suggesting its involvement in lipid metabolism [PMC6851116]. It also appears to be part of the molecular mechanisms through which osthole alleviates neuropathic pain by interacting with genes involved in metabolic pathways and gut microbiota modulation [PMC8860327]. Furthermore, MIR331 has been identified as interacting with various genes on ovine chromosome 3 (OAR3), which may have implications for genetic studies in sheep [PMC8355708]. Lastly, it interacts with numerous protein-coding genes and non-coding RNAs within the cell's regulatory networks, highlighting its multifaceted role within cellular processes [PMC9730017][PMC5458088][PMC6732937][PMC8122139][PMC6824518][PMC3956820][PMC5320387][PMC8795515[PMC5458088][PMC6732937][PMC8122139][PMC6824518][PMC3956820][PMC5320387][PMC8795515].
Literature search
78 open access papers mention hsa-mir-331
(231 sentences)
(231 sentences)
Sequence
104961
reads,
805
reads per million, 126 experiments
gaguuugguuuuguuuggguuuguuCUAGGUAUGGUCCCAGGGAUCCcagaucaaaccagGCCCCUGGGCCUAUCCUAGAAccaaccuaagcuc
............(((((((((.((((((((.((((.(((((((...((...........)).))))))).)))))))))))).)))))))))..
............(((((((((.((((((((.((((.(((((((...((...........)).))))))).)))))))))))).)))))))))..
Structure
gaguuugguuuu u U U AUC agau
guuuggguu guuCUAGG AUGG CCCAGGG Cc c
||||||||| |||||||| |||| ||||||| || a
cgaauccaa cAAGAUCC UAUC GGGUCCC Gg a
----------cu c - C --C acca
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].
Genome context
chr12: 95308420-95308513 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-331
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature hsa-miR-331-5p
| Accession | MIMAT0004700 |
| Description | Homo sapiens hsa-miR-331-5p mature miRNA |
| Sequence | 26 - CUAGGUAUGGUCCCAGGGAUCC - 47 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-331-3p
| Accession | MIMAT0000760 |
| Description | Homo sapiens hsa-miR-331-3p mature miRNA |
| Sequence | 61 - GCCCCUGGGCCUAUCCUAGAA - 81 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
References
|
