Stem-loop hsa-mir-151a

Accession

MI0000809

Symbol

HGNC: MIR151A

Description

Homo sapiens hsa-mir-151a precursor miRNA mir-28

Gene
family

RF00655; mir-28

Literature search

102 open access papers mention hsa-mir-151a
(504 sentences)

Sequence

523928 reads, 2524 reads per million, 157 experiments

uuuccugcccUCGAGGAGCUCACAGUCUAGUaugucucauccccuaCUAGACUGAAGCUCCUUGAGGacagggauggucauacucaccuc
.((((((.((((((((((((..((((((((((.(........).)))))))))).)))))))))))).)))))).(((.......)))..

Structure

---------------u      c            CA          u ucu 
                uuccug ccUCGAGGAGCU  CAGUCUAGUa g   c
                |||||| ||||||||||||  |||||||||| |    
                agggac GGAGUUCCUCGA  GUCAGAUCau c   a
cuccacucauacuggu      a            -A          c ccu 

Annotation confidence Not enough data

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr8: 140732564-140732653 [-]

Disease association

hsa-mir-151a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-151a-5p

• Accession: MIMAT0004697
• Description: Homo sapiens hsa-miR-151a-5p mature miRNA
• Sequence: 11 - UCGAGGAGCUCACAGUCUAGU - 31
• Evidence: experimental ; cloned [4-5]

Mature hsa-miR-151a-3p

• Accession: MIMAT0000757
• Description: Homo sapiens hsa-miR-151a-3p mature miRNA
• Sequence: 47 - CUAGACUGAAGCUCCUUGAGG - 67
• Evidence: experimental ; cloned [3-5], Northern [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


4. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


5. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365