miRBase entry: hsa-mir-326

Stem-loop hsa-mir-326

Homo sapiens hsa-mir-326 precursor miRNA
Gene family
MIPF0000143; mir-326

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR326 is a microRNA that has been associated with progression-free survival (PFS) in certain cases, such as miR155, miR210, and miR130a [PMC7073212]. It has been found that miR29a targets HIV-1 US vRNA and leads to translational repression, while miR133b, miR138-5, MIR326, miR149-5p, and miR92a-3p have been shown to reduce HIV-1 replication [PMC9237370]. Additionally, the expression of MIR326 negatively correlates with HIV-1 infection [PMC9237370].

Literature search
75 open access papers mention hsa-mir-326
(392 sentences)


1560 reads, 29 reads per million, 90 experiments

cuc        guu          c       uuguga      -g  g 
   aucugucu   gggcuggagg agggccu      aggcgg  ug u
   ||||||||   |||||||||| |||||||      ||||||  || g
   uaggcgga   cccGACCUCC UCCCGGG      UCCgcu  ac c
acu        -gc          U       ----UC      ag  u 

Annotation confidence Not enough data
Do you think this miRNA is real?
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3]. miR-326 cloned in [3] has a 1 nt 3' extension (U), which is incompatible with the genome sequence.

Genome context
chr11: 75335092-75335186 [-]

Disease association
hsa-mir-326 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-326

Accession MIMAT0000756
Description Homo sapiens hsa-miR-326 mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  3. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365