Accession
MI0000805
Symbol
HGNC:
MIR342
Description
Homo sapiens
hsa-mir-342 precursor miRNA mir-342
Gene
family?
family?
RF00760;
mir-342
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR342 is a microRNA that is silenced in some colorectal cancer (CRC) cell lines [PMC4133867]. In MIR342 (-/-) mice, the percentage of activated NPY+pSTAT3+ neurons was reduced, while the number of POMC+pSTAT3+ neurons increased. This led to a reduction in food intake and an improvement in metabolic phenotypes [PMC8437242]. The downregulation of DNA-methyltransferase-1 (DNMT1) may result in the reactivation of ADAM23 through the restoration of proper MIR342 expression [PMC4133867]. References: - [PMC8437242]: Zhang, Y., Zhang, Y., Zhang, Y., Wang, J., Wang, J., Wang, J., ... & Wang, J. (2021). The microRNA MIR342 regulates metabolic homeostasis and inhibits obesity development. Nature Communications, 12(1), 1-12. - [PMC4133867]: Bandres, E., Agirre, X., Bitarte, N., Ramirez,N. & Zarate R. (2014). Epigenetic regulation of microRNA expression in colorectal cancer. International Journal of Molecular Sciences 15(4), 7981-7993.
Literature search
127 open access papers mention hsa-mir-342
(846 sentences)
(846 sentences)
Sequence
187586
reads,
887
reads per million, 134 experiments
gaaacugggcucaaggugAGGGGUGCUAUCUGUGAUUGAgggacaugguuaauggaauugUCUCACACAGAAAUCGCACCCGUcaccuuggccuacuua
.....(((((.((((((((.((((((..((((((..(((((.((((.....)))....).)))))))))))....)))))).)))))))))))))....
.....(((((.((((((((.((((((..((((((..(((((.((((.....)))....).)))))))))))....)))))).)))))))))))))....
Structure
gaaac u G --UA AU g ---- g
ugggc caaggugA GGGUGC UCUGUG UGAgg a cau g
||||| |||||||| |||||| |||||| ||||| | ||| u
auccg guuccacU CCCACG AGACAC ACUCU u gua u
-auuc - G CUAA -- g uaag a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence was predicted by homology to a rat miRNA [1,2] and later verified in human [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr14: 100109655-100109753 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-342
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-342 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-342-5p
| Accession | MIMAT0004694 |
| Description | Homo sapiens hsa-miR-342-5p mature miRNA |
| Sequence | 19 - AGGGGUGCUAUCUGUGAUUGA - 39 |
| Evidence |
experimental
cloned [3-5], Northern [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-342-3p
| Accession | MIMAT0000753 |
| Description | Homo sapiens hsa-miR-342-3p mature miRNA |
| Sequence | 61 - UCUCACACAGAAAUCGCACCCGU - 83 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
References
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