Accession
MI0000802
Symbol
HGNC:
MIR340
Description
Homo sapiens
hsa-mir-340 precursor miRNA mir-340
Gene
family?
family?
RF00761;
mir-340
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR340 is a host microRNA implicated in the regulation of antiviral responses, specifically targeting the antiviral factors RIG-I and OAS2, which are crucial in the host's defense against influenza virus infection [PMC6370596]. The study's findings suggest that MIR340 may play a role in modulating immunity, as its inhibition could potentially enhance the immune response against influenza by reducing the suppression of these key antiviral proteins [PMC6370596]. The identification of MIR340 target sites within the 3สน UTR of RIG-I at positions 1,657 and 1,809 supports the strategy of targeting host miRNAs as a novel therapeutic approach to combat influenza virus infection [PMC6370596]. This approach is consistent with previous reports that miRNA-dependent strategies have been developed for viral infections and that modulating miRNA activity can have a significant impact on viral resistance, as seen with miR144-deficient mice and their resistance to influenza virus [PMC6370596].
Literature search
75 open access papers mention hsa-mir-340
(422 sentences)
(422 sentences)
Sequence
271302
reads,
1711
reads per million, 133 experiments
uuguaccuggugugaUUAUAAAGCAAUGAGACUGAUUgucauaugucguuugugggaUCCGUCUCAGUUACUUUAUAGCcauaccugguaucuua
..(((((.((((((.((((((((...((((((.((((.(((((.......))))))))).))))))....)))))))).)))))).)))))....
..(((((.((((((.((((((((...((((((.((((.(((((.......))))))))).))))))....)))))))).)))))).)))))....
Structure
--uu u a -CAA U g ug
guacc ggugug UUAUAAAG UGAGAC GAUU ucaua u
||||| |||||| |||||||| |||||| |||| ||||| c
uaugg ccauac GAUAUUUC ACUCUG CUag ggugu g
auuc u C AUUG C - uu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2]. Landgraf et al. show that the 5' product is the predominant one in human, mouse and rat [3], in contrast to the previous annotation. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr5: 180015303-180015397 [-]
Disease association
hsa-mir-340 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-340-5p
| Accession | MIMAT0004692 |
| Description | Homo sapiens hsa-miR-340-5p mature miRNA |
| Sequence | 16 - UUAUAAAGCAAUGAGACUGAUU - 37 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-340-3p
| Accession | MIMAT0000750 |
| Description | Homo sapiens hsa-miR-340-3p mature miRNA |
| Sequence | 58 - UCCGUCUCAGUUACUUUAUAGC - 79 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
|
