Stem-loop hsa-mir-377

Accession

MI0000785

Symbol

HGNC: MIR377

Description

Homo sapiens hsa-mir-377 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR377, a microRNA, is notably overexpressed in GH, TSH, and PRL adenoma clusters and is implicated in various cellular processes [PMC7652879]. It plays a role in demethylation-induced upregulation of genes like SLIT1 and PRLR in these adenomas [PMC7652879]. MIR377 is also involved in myocardial regeneration and angiogenesis by targeting genes associated with inflammation, oxidative stress, and angiogenesis [PMC7527411]. It demonstrates significant enrichment in heart failure diet groups [PMC7527411] and can regulate metastatic capability by inhibiting epithelial-mesenchymal transition (EMT) and the Wnt/β-catenin pathway [PMC9212183]. In gastric cancer cells, MIR377 affects cell proliferation by altering the cell cycle phases [PMC5795907] and interacts with various genetic elements like NEAT1 pseudogenes and other miRNAs [PMC9730017]. It is among the top upregulated miRNAs after IFN-γ stimulation [PMC8010072] and has been identified as a potential transcriptional repressor of HO-1 protein expression influencing microglial polarization after intracerebral hemorrhage (ICH) prognosis [PMC6109777]. Furthermore, MIR377 expression has been studied for its regulatory relationships with other factors affecting the permeability of the blood-brain barrier (BBB) in glioma-conditioned endothelial cells (GECs) [PMC6180493], while its downregulation has been observed upon treatment with luteolin as validated by qRT-PCR analysis [PMC4791268].

Literature search

65 open access papers mention hsa-mir-377
(519 sentences)

Sequence

2013 reads, 24 reads per million, 87 experiments

uugagcAGAGGUUGCCCUUGGUGAAUUCgcuuuauuuauguugaAUCACACAAAGGCAACUUUUGUuug
..((((((((((((((.(((((((.(((((.........).)))))))).))).)))))))))))))).

Structure

uu              C   -    A    - uuu 
  gagcAGAGGUUGCC UUG GUGA UUCg c   a
  |||||||||||||| ||| |||| |||| |   u
  uuUGUUUUCAACGG AAC CACU Aagu g   u
-g              A   A    -    u uau 

Annotation confidence High

Genome context

chr14: 101062050-101062118 [+]

Clustered miRNAs

14 other miRNAs are < 10 kb from hsa-mir-377

Disease association

hsa-mir-377 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-377-5p

• Accession: MIMAT0004689
• Description: Homo sapiens hsa-miR-377-5p mature miRNA
• Sequence: 7 - AGAGGUUGCCCUUGGUGAAUUC - 28
• Evidence: experimental ; cloned [3]

Mature hsa-miR-377-3p

• Accession: MIMAT0000730
• Description: Homo sapiens hsa-miR-377-3p mature miRNA
• Sequence: 45 - AUCACACAAAGGCAACUUUUGU - 66
• Evidence: experimental ; cloned [1-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267