Accession
MI0000783
Symbol
HGNC:
MIR375
Description
Homo sapiens
hsa-mir-375 precursor miRNA mir-375
Gene
family?
family?
RF00700;
mir-375
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR375 is a microRNA specifically expressed in islet cells and is implicated in the differentiation of embryonic stem cells into liver and insulin-secreting cells, suggesting a role in early islet development [PMC4700298]. It has been utilized in an integrated analysis with miR371 to predict the risk of aggressive germ cell malignancies and teratoma in patients with residual disease post-chemotherapy [PMC8575592]. Additionally, MIR375 has been associated with the inhibition of autophagy, which may enhance the chemosensitivity of cancer cells when coupled with WWOX [PMC8939209]. Furthermore, it has been suggested that MIR375 can be down-regulated to potentially improve dendritic cell function by a factor known as PB1 [PMC5360757]. In terms of diagnostic potential, MIR375 is among several miRNAs that may show changes in concentration prior to cardiac troponin I during cardiac events, indicating its potential as an early biomarker [PMC3922900].
Literature search
256 open access papers mention hsa-mir-375
(1718 sentences)
(1718 sentences)
Sequence
258390
reads,
1004
reads per million, 138 experiments
ccccGCGACGAGCCCCUCGCACAAACCggaccugagcguUUUGUUCGUUCGGCUCGCGUGAggc
.((((((.((((((...((.(((((.((........)).))))).))...)))))))))).)).
.((((((.((((((...((.(((((.((........)).))))).))...)))))))))).)).
Structure
c - A CCU C C gac cc cGCG CGAGCC CG ACAAA Cg c || |||| |||||| || ||||| || gg GUGC GCUCGG GC UGUUU gc u c A - CUU U u gag
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr2: 219001645-219001708 [-]
Disease association
hsa-mir-375 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-375-3p
| Accession | MIMAT0000728 |
| Description | Homo sapiens hsa-miR-375-3p mature miRNA |
| Sequence | 40 - UUUGUUCGUUCGGCUCGCGUGA - 61 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-375-5p
| Accession | MIMAT0037313 |
| Description | Homo sapiens hsa-miR-375-5p mature miRNA |
| Sequence | 5 - GCGACGAGCCCCUCGCACAAACC - 27 |
| Evidence | not_experimental |
References
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