miRBase entry: hsa-mir-370

Stem-loop hsa-mir-370

Homo sapiens hsa-mir-370 precursor miRNA
Gene family
MIPF0000167; mir-370

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR370 is a microRNA that has been implicated in various cancers, including head and neck cancers, PCNSL, GC, and lung cancer. It has been shown to affect the prognosis of PCNSL patients and is considered a potential therapeutic target [PMC9428130]. In GC, the overexpression of MIR370 has been found to enhance cell proliferation, EMT, and invasion through the downregulation of UQCRC2 levels [PMC7378919]. MIR370 has also been shown to be regulated by IL-6 and DNMT1 in the context of GC [PMC5885281]. In lung cancer, MIR370 has been found to inhibit proliferation, angiogenesis, migration in vitro and growth and metastasis in vivo [PMC5675699]. It has also been shown to target EGFR expression [PMC5675699]. Additionally, MIR370 is involved in hematopoietic development and leukemogenesis by targeting FOXM1 [PMC7565099] [PMC6213964] [PMC3533721] [PMC9454643]. It is regulated by distinct gene expression programs on different chromosomes [PMC7565099'>PMC7565099]. Furthermore, MIR370 is known to downregulate the expression of MGMT through sequence complementarity with its mRNA [PMC7958331].

- PMC5354851
- PMC9428130
- PMC6158169
- PMC4998167
- PMC7378919
- PMC5885281
- PMC5011744
- PMC9373174
- PMC7565099
- PMC8065645
- PMC6183594

Literature search
76 open access papers mention hsa-mir-370
(823 sentences)


12486 reads, 138 reads per million, 96 experiments

      agaa       CA      U    UUA   agc 
agacag    gcCAGGU  CGUCUC GCAG   Cac   u
||||||    |||||||  |||||| ||||   |||   c
ucuguc    UGGUCCA  GUGGGG CGUC   Gug   a
      ----       AG      U    --C   agc 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr14: 100911139-100911213 [+]

Disease association
hsa-mir-370 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-370-3p

Accession MIMAT0000722
Description Homo sapiens hsa-miR-370-3p mature miRNA
Evidence experimental
cloned [1-3], Illumina [4]
Database links
Predicted targets

Mature hsa-miR-370-5p

Accession MIMAT0026483
Description Homo sapiens hsa-miR-370-5p mature miRNA
Evidence experimental
Illumina [4]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267

  4. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45