Stem-loop hsa-mir-30e

Accession

MI0000749

Symbol

HGNC: MIR30E

Description

Homo sapiens hsa-mir-30e precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR30E is a microRNA that has been identified as dysregulated in the plasma of schizophrenia patients, suggesting a potential role in the pathophysiology of the disorder [PMC4977811]. It is one of several microRNAs that have been found to be altered in patients, indicating that microRNA dysregulation could be a feature of schizophrenia [PMC4977811]. Notably, MIR30E is co-located with mir30c-1 within an intron of the Nfyc gene, which is an interesting genomic context as this gene's promoter region contains a CpG island [PMC6195825]. The presence of MIR30E within this particular genomic region could imply regulatory mechanisms involving epigenetic modifications that are relevant to schizophrenia and warrant further investigation [PMC6195825].

Literature search

357 open access papers mention hsa-mir-30e
(1687 sentences)

Sequence

736258 reads, 2874 reads per million, 149 experiments

gggcagucuuugcuacUGUAAACAUCCUUGACUGGAAGcuguaagguguucagaggagCUUUCAGUCGGAUGUUUACAGCggcaggcugcca
.((((((((..(((.((((((((((((..(((((((((((.(...(....)...).))))))))))))))))))))))).))))))))))).

Structure

g        uu   a            UU           g aag u 
 ggcagucu  gcu cUGUAAACAUCC  GACUGGAAGcu u   g g
 ||||||||  ||| ||||||||||||  ||||||||||| |   |  
 ccgucgga  cgg GACAUUUGUAGG  CUGACUUUCga g   c u
a        --   C            --           g aga u 

Annotation confidence High

Comments

This sequence is the predicted human homologue of mouse miR-30e [1,2,4]. Mature products from both arms of the precursor (hsa-miR-30e-5p and hsa-miR-30e-3p) were later independently verified in human myelocytic leukemia (HL-60) cells [3]. Landgraf et al. later showed that the 5' product is the predominant one [5]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].

Genome context

chr1: 40754355-40754446 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-30e

Mature hsa-miR-30e-5p

• Accession: MIMAT0000692
• Description: Homo sapiens hsa-miR-30e-5p mature miRNA
• Sequence: 17 - UGUAAACAUCCUUGACUGGAAG - 38
• Evidence: experimental ; cloned [3,5-6]

Mature hsa-miR-30e-3p

• Accession: MIMAT0000693
• Description: Homo sapiens hsa-miR-30e-3p mature miRNA
• Sequence: 59 - CUUUCAGUCGGAUGUUUACAGC - 80
• Evidence: experimental ; cloned [3,5]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


5. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73