Stem-loop hsa-mir-99b

Accession

MI0000746

Symbol

HGNC: MIR99B

Description

Homo sapiens hsa-mir-99b precursor miRNA

Literature search

137 open access papers mention hsa-mir-99b
(407 sentences)

Sequence

662095 reads, 1203 reads per million, 130 experiments

ggcaccCACCCGUAGAACCGACCUUGCGgggccuucgccgcacaCAAGCUCGUGUCUGUGGGUCCGuguc
(((((..(((((((((..(((.((((.(.(((....))).)...)))).)))..)))))))))..)))))

Structure

     cC         AC   C    --C g   c 
ggcac  ACCCGUAGA  CGA CUUG   G ggc u
|||||  |||||||||  ||| ||||   | |||  
cuguG  UGGGUGUCU  GCU GAAC   c ccg u
     CC         GU   C    aca g   c 

Annotation confidence High

Comments

This sequence is the predicted human homologue of mouse miR-99b, cloned from mouse brain [1] and embryonic stem cells [2,3]. Its expression was later validated in human [4-6].

Genome context

chr19: 51692612-51692681 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-99b

Disease association

hsa-mir-99b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-99b-5p

• Accession: MIMAT0000689
• Description: Homo sapiens hsa-miR-99b-5p mature miRNA
• Sequence: 7 - CACCCGUAGAACCGACCUUGCG - 28
• Evidence: experimental ; cloned [4-6]

Mature hsa-miR-99b-3p

• Accession: MIMAT0004678
• Description: Homo sapiens hsa-miR-99b-3p mature miRNA
• Sequence: 45 - CAAGCUCGUGUCUGUGGGUCCG - 66
• Evidence: experimental ; cloned [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


4. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


5. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73