Accession
MI0000742
Symbol
HGNC:
MIR34B
Description
Homo sapiens
hsa-mir-34b precursor miRNA mir-34
Gene
family?
family?
RF00456;
mir-34
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR34B is a member of the miR34 family, which includes miR34A, MIR34B, and miR34C, and is characterized as a tumor suppressor with a role in various cellular processes related to cancer development [PMC4039115]. Specifically, MIR34B has been identified in the MB436 cell line, which is a subtype of triple-negative breast cancer (TNBC), indicating its presence in this particular breast cancer subtype [PMC8261273]. The tumor-suppressive functions of the miR34 family encompass regulation of cell cycling, induction of apoptosis, influence on somatic cell reprogramming, and effects on metastasis [PMC4039115].
Literature search
463 open access papers mention hsa-mir-34b
(2668 sentences)
(2668 sentences)
Sequence
3243
reads,
437
reads per million, 69 experiments
gugcucgguuugUAGGCAGUGUCAUUAGCUGAUUGuacuguggugguuaCAAUCACUAACUCCACUGCCAUcaaaacaaggcac
(((((..((((...(((((((...((((.((((((((((.....)).))))))))))))...)))))))....))))..)))))
(((((..((((...(((((((...((((.((((((((((.....)).))))))))))))...)))))))....))))..)))))
Structure
cg -gUA UCA C - g
gugcu guuu GGCAGUG UUAG UGAUUGua cu u
||||| |||| ||||||| |||| |||||||| || g
cacgg caaa CCGUCAC AAUC ACUAACau gg g
aa acUA CUC - u u
Annotation confidence
High
Do you think this miRNA is real?
Comments
Houbaviy et al. cloned 3 closely related sequences from mouse embryonic stem cells [1], and named them miR-34a, miR-34b and miR-172. These names have been remapped to miR-34c (MIR:MI0000403), miR-34b (MIR:MI0000404) and miR-34a (MIR:MI0000584) to clarify homology with human sequences. The predominant mature miRNA in human is expressed from the 3' arm (in contrast to previous annotation) [2]. Both arms express mature products in mouse.
Genome context
chr11: 111512938-111513021 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-34b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-34b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-34b is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-34b is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-34b-5p
| Accession | MIMAT0000685 |
| Description | Homo sapiens hsa-miR-34b-5p mature miRNA |
| Sequence | 13 - UAGGCAGUGUCAUUAGCUGAUUG - 35 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-34b-3p
| Accession | MIMAT0004676 |
| Description | Homo sapiens hsa-miR-34b-3p mature miRNA |
| Sequence | 50 - CAAUCACUAACUCCACUGCCAU - 71 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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