Accession
MI0000740
Symbol
HGNC:
MIR219A2
Description
Homo sapiens
hsa-mir-219a-2 precursor miRNA mir-219
Gene
family?
family?
RF00251;
mir-219
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR219A2 is a microRNA implicated in the differentiation of oligodendrocytes and the process of remyelination, and it has been observed to be downregulated in Alzheimer's disease (AD) patients' brains [PMC9822908]. In the context of AD, a study has shown that oligodendrocytes express fewer transcripts of genes like MIR219A2, which is essential for the maturation of myelin-forming cells [PMC6980793]. This downregulation was identified as a characteristic feature distinguishing clusters Oligo1 and Oligo2 in gene expression profiles [PMC6980793]. Furthermore, MIR219A2's reduced expression correlates with a decrease in genes that are crucial for myelination processes, such as those involved in axonal guidance and actin cytoskeleton rearrangement [PMC6980793]. The study's heatmap analysis specifically highlighted MIR219A2 among genes with significantly reduced expression that are typically involved in promoting myelination by aiding the differentiation from precursor cells to mature myelin-forming cells [PMC6980793]. In addition to AD, MIR219A2 upregulation has been noted relative to other subtypes in amyotrophic lateral sclerosis with transactive response DNA-binding protein 43 kDa pathology (ALS-TD), suggesting its role in transcriptional and translational dysregulation within this disease context as well [PMC9822908].
Literature search
70 open access papers mention hsa-mir-219a-2
(247 sentences)
(247 sentences)
Sequence
149935
reads,
3045
reads per million, 66 experiments
acucaggggcuucgccacUGAUUGUCCAAACGCAAUUCUuguacgagucugcggccaaccgAGAAUUGUGGCUGGACAUCUGUggcugagcuccggg
.(((.(((((((.(((((.(((.(((((..(((((((((((...(.(((...))))...)))))))))))..)))))))).))))).))))))))))
.(((.(((((((.(((((.(((.(((((..(((((((((((...(.(((...))))...)))))))))))..)))))))).))))).))))))))))
Structure
a a c U U AA uac a u cuc ggggcuu gccac GAU GUCCA CGCAAUUCUug g guc ||| ||||||| ||||| ||| ||||| ||||||||||| | ||| g ggg ccucgag cggUG CUA CAGGU GUGUUAAGAgc c cgg - - u U - CG caa - c
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR [2]. The mature products were later verified in human [3]. Two hairpin precursor structures are predicted, mir-219-1 on chromosome 6 (MIR:MI0000296) and mir-219-2 on chromosome 9 (MIR:MI0000740) [2].
Genome context
chr9: 128392618-128392714 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-219a-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-219a-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-219a-5p
| Accession | MIMAT0000276 |
| Description | Homo sapiens hsa-miR-219a-5p mature miRNA |
| Sequence | 19 - UGAUUGUCCAAACGCAAUUCU - 39 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-219a-2-3p
| Accession | MIMAT0004675 |
| Description | Homo sapiens hsa-miR-219a-2-3p mature miRNA |
| Sequence | 62 - AGAAUUGUGGCUGGACAUCUGU - 83 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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