Stem-loop hsa-mir-30c-1

Accession

MI0000736

Symbol

HGNC: MIR30C1

Description

Homo sapiens hsa-mir-30c-1 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR30C1 is a gene that encodes a microRNA involved in various cellular processes and is located on chromosome 1p34.2 [PMC5400605]. It interacts with the protein HNRNPK and is part of a cluster that includes another gene, MIR30C2, which encodes the same mature miRNA, hsa-mir-30c [PMC9730017]. In a study using cBioPortal, MIR30C1 was found to have frequent amplifications and significant changes in the levels of hsa-mir-30c in many patients [PMC4129468]. Additionally, MIR30C1 exhibited a high rate of loss at 88% in samples with miR-30c cluster deletion [PMC5400605]. In contrast to MIR30C2 which was deleted in 4 out of 5 cases with miR-30c cluster deletion, MIR30C1 was deleted in only 2 out of 5 cases [PMC5400605]. The clones used for studying these genes included RP11-170L4 for MIR30C1 and RP11-756H9 for MIR30C2 [PMC5400605]. These findings were part of an array Comparative Genomic Hybridization study that investigated genes expressing let-7a and miR-30c clusters on specific chromosomal locations [PMC5356719].

Literature search

384 open access papers mention hsa-mir-30c-1
(1839 sentences)

Sequence

279699 reads, 1532 reads per million, 159 experiments

accaugcuguagugugUGUAAACAUCCUACACUCUCAGCugugagcucaagguggCUGGGAGAGGGUUGUUUACUCCuucugccaugga
.(((((..((((...(.(((((((.(((...(((((((((....(((...)))))))))))).))).))))))).)...))))))))).

Structure

a     cu    ugu U       U   ACA         guga   c 
 ccaug  guag   g GUAAACA CCU   CUCUCAGCu    gcu  
 |||||  ||||   | ||||||| |||   |||||||||    ||| a
 gguac  cguc   C CAUUUGU GGG   GAGGGUCgg    ugg  
a     --    uuC U       U   --A         ----   a 

Annotation confidence High

Comments

miR-30c was cloned from mouse heart and brain tissues by Lagos-Quintana et al. [1]. Two human hairpin precursor sequences are predicted based on homology with the mouse sequences, on chromosomes 1 (MIR:MI0000736) and 6 (MIR:MI0000254) [3]. Expression of miR-30c was later validated in human HL-60 leukemia cells [2].

Genome context

chr1: 40757284-40757372 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-30c-1

Mature hsa-miR-30c-5p

• Accession: MIMAT0000244
• Description: Homo sapiens hsa-miR-30c-5p mature miRNA
• Sequence: 17 - UGUAAACAUCCUACACUCUCAGC - 39
• Evidence: experimental ; cloned [2,4-6]

Mature hsa-miR-30c-1-3p

• Accession: MIMAT0004674
• Description: Homo sapiens hsa-miR-30c-1-3p mature miRNA
• Sequence: 56 - CUGGGAGAGGGUUGUUUACUCC - 77
• Evidence: experimental ; cloned [5]

References

1. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


5. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


6. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73