Accession
MI0000727
Symbol
HGNC:
MIR128-2
Description
Homo sapiens
hsa-mir-128-2 precursor miRNA mir-128
Gene
family?
family?
RF00649;
mir-128
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR128-2 is a microRNA gene implicated in various cellular processes, including apoptosis and drug resistance in cancer [PMC3566410]. It is co-expressed with its host gene ARPP21, and mutant TP53 has been shown to upregulate both MIR128-2 and ARPP21, suggesting a regulatory interaction [PMC4302087]. A specific A13G mutation in MIR128-2 disrupts the processing of its primary transcript, leading to reduced apoptosis and increased resistance to dexamethasone in t(4;11) ALL cells [PMC9406077]. Additionally, the R175H mutant TP53 variant upregulates MIR128-2 expression, which then targets E2F5 to enhance p21 expression, inhibiting apoptosis and conferring resistance to several chemotherapeutic agents [PMC7749743]. MIR128-2 has been identified as an oncogenic microRNA with prognostic value for gastrointestinal integrity (GI) and is part of a three-miRNA signature (miGISig) predictive of GI-related clinical outcomes [PMC7802300]. It shares the mature miR-128 sequence with MIR128-1 but has distinct regulatory roles across different cancer types [PMC7802300]. The expression of MIR128-2 relative to its host gene ARPP21 remains an area for further investigation due to the presence of a Pol III promoter in its 5′ flanking region [PMC5346679].
Literature search
174 open access papers mention hsa-mir-128-2
(979 sentences)
(979 sentences)
Sequence
175904
reads,
1106
reads per million, 134 experiments
ugugcagugggaagGGGGGCCGAUACACUGUACGAGAgugaguagcaggucUCACAGUGAACCGGUCUCUUUcccuacuguguc
...((((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).))))))))...
...((((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).))))))))...
Structure
ugu a AUA AC g gag gcaguggg agGGGGGCCG CACUGU GAGA u u |||||||| |||||||||| |||||| |||| | ugucaucc UUUCUCUGGC GUGACA CUcu g a cug c CAA -- g acg
Annotation confidence
High
Do you think this miRNA is real?
Comments
The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical [3]. The sequences are therefore renamed mir-128-1 and mir-128-2.
Genome context
chr3: 35744476-35744559 [+]
Disease association
hsa-mir-128-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-128-3p
| Accession | MIMAT0000424 |
| Description | Homo sapiens hsa-miR-128-3p mature miRNA |
| Sequence | 52 - UCACAGUGAACCGGUCUCUUU - 72 |
| Evidence |
experimental
cloned [3], Illumina [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-128-2-5p
| Accession | MIMAT0031095 |
| Description | Homo sapiens hsa-miR-128-2-5p mature miRNA |
| Sequence | 15 - GGGGGCCGAUACACUGUACGAGA - 37 |
| Evidence |
experimental
Illumina [4] |
References
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