Accession
MI0000651
Symbol
HGNC:
MIR1-1
Description
Homo sapiens
hsa-mir-1-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1-1 is a muscle-specific microRNA primarily associated with skeletal muscle development in mammals [PMC5424345]. It is one of the canonical cardiac myomiRs, which include MIR1-1, MIR126, MIR133, and MIR208, and its expression is crucial during the early stages of cardiogenesis [PMC6828809][PMC7123062[PMC7123062]. This microRNA is also involved in the regulation of cardiac contraction and embryonic angiogenesis [PMC8624534]. It forms part of a bicistronic cluster with miR133a, which collectively regulates multiple mRNAs involved in muscle differentiation and myogenesis [PMC9185982][PMC5137429[PMC5137429]. Moreover, MIR1-1 has been implicated in MET-dependent proliferation in colorectal cancer (CRC) and has been observed to have a copy number gain in a subset of patients with this disease [PMC4967895]. In the context of prostate cancer (PCa), differentially expressed genes (DEGs) have been identified following miR-1 pretreatment by searching databases such as GEO and ArrayExpress [PMC6236292]. Additionally, research has identified that sequence variations in MIR1-1 are not associated with long QT syndrome (LQTS) within certain cohorts studied [PMC4196592], indicating its specificity to muscle-related functions.
Literature search
517 open access papers mention hsa-mir-1-1
(2693 sentences)
(2693 sentences)
Sequence
6744881
reads,
3396
reads per million, 153 experiments
ugggaaACAUACUUCUUUAUAUGCCCAUauggaccugcuaagcuaUGGAAUGUAAAGAAGUAUGUAUcuca
(((((.((((((((((((((((..((((((((.....)))...))))).)))))))))))))))).)))))
(((((.((((((((((((((((..((((((((.....)))...))))).)))))))))))))))).)))))
Structure
a GC --- a
uggga ACAUACUUCUUUAUAU CCAUa ugg c
||||| |||||||||||||||| ||||| ||| c
acucU UGUAUGAAGAAAUGUA GGUau auc u
A -A cga g
Annotation confidence
High
Do you think this miRNA is real?
Comments
Lagos-Quintana et al. [1] reported the cloning of miR-1b, miR-1c and miR-1d. The mature processed miR sequences are identical apart from the 3' residues (A in mir-1b, C in mir-1c and UU in mir-1d). The 3' residues of both miR-1b and miR-1c conflict with the predicted stem-loop precursor sequence shown here and these sequences are not found in current assemblies of human and mouse genomes. It is suggested that polyA polymerase may add 1-3 nts to the 3' end of the mature transcript (Tom Tuschl, pers. comm.). The common 21 nts of the 3 reported miR sequences have been rationalised here and named miR-1. There are 2 pairs of orthologous putative hairpin precursor structures named mir-1-1 (human MIR:MI0000651, mouse MIR:MI0000139), and mir-1-2 (human MIR:MI0000437, mouse MIR:MI0000652). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr20: 62554306-62554376 [+]
Disease association
hsa-mir-1-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1-3p
| Accession | MIMAT0000416 |
| Description | Homo sapiens hsa-miR-1-3p mature miRNA |
| Sequence | 46 - UGGAAUGUAAAGAAGUAUGUAU - 67 |
| Evidence |
experimental
cloned [2], Illumina [3] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-1-5p
| Accession | MIMAT0031892 |
| Description | Homo sapiens hsa-miR-1-5p mature miRNA |
| Sequence | 7 - ACAUACUUCUUUAUAUGCCCAU - 28 |
| Evidence | not_experimental |
| Database links |
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| Predicted targets |
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References
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