Accession
MI0000480
Symbol
HGNC:
MIR154
Description
Homo sapiens
hsa-mir-154 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR154 is a microRNA belonging to a large cluster located on chromosome 14q32.31, known to contain over 40 intergenic microRNAs, and is transcribed from the maternal chromosome [PMC3919614], [PMC7794215]. It is part of the miR655 miRNA cluster, which includes several other microRNAs with available expression data [PMC7465874]. MIR154 has been implicated in the regulation of fibrosis in various organs and has been highlighted as a potential diagnostic biomarker for distinguishing between pulmonary granuloma and adenocarcinoma [PMC7794215], [PMC9400731]. It has also been associated with negative regulation in gene sets related to myocardial fibrosis and the metastatic behavior of non-small lung cancer cells [PMC6465659]. In studies on immune cells, MIR154 expression was found to be downregulated in T lymphocytes and monocytes but was higher in B cells compared to neutrophils; however, its expression was consistently upregulated in human cell lines upon Snail overexpression [PMC6122344]. Additionally, MIR154 has been shown to be down-regulated in HPV16-positive cervical carcinoma compared to normal cervix samples but not vice versa [PMC4288222]. These findings suggest that MIR154 plays a complex role across various biological processes and diseases.
Literature search
59 open access papers mention hsa-mir-154
(142 sentences)
(142 sentences)
Sequence
2304
reads,
63
reads per million, 69 experiments
gugguacuugaagaUAGGUUAUCCGUGUUGCCUUCGcuuuauuugugacgAAUCAUACACGGUUGACCUAUUuuucaguaccaa
.(((((((.((((((((((((.((((((((.(.((((.......)))).)...)).)))))).)))))))))))).))))))).
.(((((((.((((((((((((.((((((((.(.((((.......)))).)...)).)))))).)))))))))))).))))))).
Structure
g u U - --C U uu ugguacu gaagaUAGGUUA CCGUGU UG C UCGc u ||||||| |||||||||||| |||||| || | |||| a accauga uuuUUAUCCAGU GGCACA AC g agug u a c U U UAA c uu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101059755-101059838 [+]
Clustered miRNAs
14 other miRNAs are < 10 kb from hsa-mir-154
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-154 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-154-5p
| Accession | MIMAT0000452 |
| Description | Homo sapiens hsa-miR-154-5p mature miRNA |
| Sequence | 15 - UAGGUUAUCCGUGUUGCCUUCG - 36 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-154-3p
| Accession | MIMAT0000453 |
| Description | Homo sapiens hsa-miR-154-3p mature miRNA |
| Sequence | 51 - AAUCAUACACGGUUGACCUAUU - 72 |
| Evidence |
experimental
cloned [2,4], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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