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MIR127 is a microRNA that functions as a repressor for RTL1 expression through the RNAi mechanism [PMC3469456]. The expression of RTL1 is significantly elevated in mice with the targeted deletion of the maternally derived IG-DMR, similar to the elevation observed in mice with increased RTL1 expression due to MIR127 repression [PMC3469456]. The increased expression of RTL1 is attributed to the repressor function of MIR127, which is encoded by RTL1as [PMC3469456]. It has been suggested that MIR127, along with other microRNAs such as miR433, regulates the expression of RTL1 through RNAi mechanism [PMC3469456]. Additionally, it has been proposed that DIO3, a gene involved in thyroid hormone metabolism, may not be solely expressed from the paternally inherited allele and may undergo partial imprinting or complete imprinting escape [PMC3469456]. Furthermore, MIR127 has been found to regulate IL-6 and TNF-α cytokine release by macrophages in lung inflammation by targeting IgG FcγRI (CD64) [PMC5247697]. Overall, MIR127 plays a crucial role in regulating gene expression and cytokine release through its repressor function.