Stem-loop hsa-mir-125a

Accession

MI0000469

Symbol

HGNC: MIR125A

Description

Homo sapiens hsa-mir-125a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR125A, a microRNA, has been evaluated for its potential as a diagnostic biomarker for differentiating between papillary thyroid carcinoma (PTC) and benign thyroid nodules through ROC curve analysis [PMC9221779]. This analysis revealed that MIR125A, along with other microRNAs, shows significant differences between the two groups [PMC9221779]. Specifically, MIR125A is involved in the regulation of granulocytic differentiation by targeting Clec5a/MDL1 expression [PMC4335136]. The inhibition of granulocytic differentiation by ASXL1-MT in 32D cells can be counteracted by the expression of Clec5a, indicating the functional importance of MIR125A in this cellular process [PMC4335136].

Literature search

389 open access papers mention hsa-mir-125a
(1745 sentences)

Sequence

408668 reads, 5127 reads per million, 138 experiments

ugccagucucuaggUCCCUGAGACCCUUUAACCUGUGAggacauccagggucACAGGUGAGGUUCUUGGGAGCCuggcgucuggcc
.(((((.(.((((((.(((((((.((((..((((((((((....))....)))))))))))).))))))).)))))).).))))).

Structure

u     u u      C       C    UA        ----  a 
 gccag c cuaggU CCUGAGA CCUU  ACCUGUGA    gg c
 ||||| | |||||| ||||||| ||||  ||||||||    ||  
 cgguc g gguCCG GGGUUCU GGAG  UGGACAcu    cc a
c     u c      A       U    --        ggga  u 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

chr19: 51693254-51693339 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-125a

Disease association

hsa-mir-125a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-125a-5p

• Accession: MIMAT0000443
• Description: Homo sapiens hsa-miR-125a-5p mature miRNA
• Sequence: 15 - UCCCUGAGACCCUUUAACCUGUGA - 38
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-125a-3p

• Accession: MIMAT0004602
• Description: Homo sapiens hsa-miR-125a-3p mature miRNA
• Sequence: 53 - ACAGGUGAGGUUCUUGGGAGCC - 74
• Evidence: experimental ; cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739