Stem-loop hsa-mir-9-3

Accession

MI0000468

Symbol

HGNC: MIR9-3

Description

Homo sapiens hsa-mir-9-3 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR9-3 is one of the three main transcripts of the MIR9 gene family, which is associated with the regulation of gene expression post-transcriptionally and is located on chromosome 15 [PMC9220270]. It, along with MIR9-1 and MIR9-2, has been identified as having a promoter region subject to methylation, which can be indicative of its regulatory role in cancer metastasis and progression [PMC8835734]. The methylation status of MIR9-3, as well as its counterparts MIR9-1 and MIR9-2, can be specifically analyzed using Methylation Specific PCR (MSP), a technique that targets the CpG region near the transcription start sites of these genes [PMC5366901]. The methylation patterns observed in these regions have been associated with both metastasis and advanced stages in primary tumors, suggesting that alterations in methylation at these sites may have significant implications for cancer prognosis [PMC8835734].

Literature search

542 open access papers mention hsa-mir-9-3
(3363 sentences)

Sequence

663593 reads, 2765 reads per million, 111 experiments

ggaggcccguuucucUCUUUGGUUAUCUAGCUGUAUGAgugccacagagccgucAUAAAGCUAGAUAACCGAAAGUagaaaugauucuca
.((((..(((((((((.(((((((((((((((.(((((..((......))..))))).))))))))))))))))).)))))))..)))).

Structure

g    cc       -  C               G     gu  ca 
 gagg  cguuucu cU UUUGGUUAUCUAGCU UAUGA  gc  c
 ||||  ||||||| || ||||||||||||||| |||||  ||   
 cucu  guaaaga GA AAGCCAAUAGAUCGA AUAcu  cg  a
a    ua       U  -               A     gc  ag 

Annotation confidence High

Genome context

chr15: 89368017-89368106 [+]

Disease association

hsa-mir-9-3 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-9-5p

• Accession: MIMAT0000441
• Description: Homo sapiens hsa-miR-9-5p mature miRNA
• Sequence: 16 - UCUUUGGUUAUCUAGCUGUAUGA - 38
• Evidence: experimental ; cloned [2]

Mature hsa-miR-9-3p

• Accession: MIMAT0000442
• Description: Homo sapiens hsa-miR-9-3p mature miRNA
• Sequence: 55 - AUAAAGCUAGAUAACCGAAAGU - 76
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739