Stem-loop hsa-mir-9-2

Accession

MI0000467

Symbol

HGNC: MIR9-2

Description

Homo sapiens hsa-mir-9-2 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR9-2 is a gene belonging to the mir-9 family, which plays a significant role in neurogenesis and is located on chromosome 5 [PMC6723948]. It is situated downstream of the LINC00461 gene, and the expression of mir-9 is notably affected by LINC00461, suggesting a regulatory relationship between these two genes [PMC6723948]. The methylation status of MIR9-2 in tumor tissues and their normal margins has been studied to understand its potential correlation with clinopathological features [PMC5019297]. Additionally, MIR9-2 has been linked to attention-deficit/hyperactivity disorder (ADHD) through its association with the rs4916723 polymorphism [PMC6723948]. The major transcript produced by MIR9-2, along with MIR9-1 and MIR9-3 genes, is miR-9-5p [PMC6162741]. Furthermore, regulatory motifs significant for the control of MIR9-2 have been identified in its genomic region [PMC5366901]. In terms of gene regulation, it has been shown that Tbr2 and Tbr1 directly repress the expression of miR-9*, which is encoded by MIR9-2 [PMC6113890].

Literature search

539 open access papers mention hsa-mir-9-2
(3355 sentences)

Sequence

663540 reads, 2776 reads per million, 111 experiments

ggaagcgaguuguuaUCUUUGGUUAUCUAGCUGUAUGAguguauuggucuucAUAAAGCUAGAUAACCGAAAGUaaaaacuccuuca
.((((.(((((.((((.(((((((((((((((.((((((.(.......))))))).))))))))))))))).)))).))))))))).

Structure

g    c     g    C               G      u ua 
 gaag gaguu uuaU UUUGGUUAUCUAGCU UAUGAg g  u
 |||| ||||| |||| ||||||||||||||| |||||| |  u
 cuuc cucaa aaUG AAGCCAAUAGAUCGA AUAcuu c  g
a    -     a    A               A      - ug 

Annotation confidence High

Genome context

chr5: 88666853-88666939 [-]

Disease association

hsa-mir-9-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-9-5p

• Accession: MIMAT0000441
• Description: Homo sapiens hsa-miR-9-5p mature miRNA
• Sequence: 16 - UCUUUGGUUAUCUAGCUGUAUGA - 38
• Evidence: experimental ; cloned [2]

Mature hsa-miR-9-3p

• Accession: MIMAT0000442
• Description: Homo sapiens hsa-miR-9-3p mature miRNA
• Sequence: 53 - AUAAAGCUAGAUAACCGAAAGU - 74
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739