Stem-loop hsa-mir-9-1

Accession

MI0000466

Symbol

HGNC: MIR9-1

Description

Homo sapiens hsa-mir-9-1 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR9-1 is a microRNA that has been studied in the context of lung cancer, and researchers have demonstrated a proapoptotic effect of MIR9-1 in patients with lung cancer [PMC9220270]. Additionally, the suppression of cell proliferation has been attributed to the action of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) [PMC9220270]. The hypermethylation of MIR130B and MIR9-1 genes has been found to be associated with the highest relative risk of death in lung cancer patients [PMC8835734]. These findings suggest that MIR9-1 may play a significant role in the pathogenesis and progression of lung cancer. Further research is needed to fully understand the mechanisms by which MIR9-1 exerts its proapoptotic effect and regulates cell proliferation, as well as its potential as a prognostic marker or therapeutic target in lung cancer.

Literature search

547 open access papers mention hsa-mir-9-1
(3386 sentences)

Sequence

663600 reads, 2789 reads per million, 111 experiments

cgggguugguuguuaUCUUUGGUUAUCUAGCUGUAUGAgugguguggagucuucAUAAAGCUAGAUAACCGAAAGUaaaaauaacccca
.(((((((....((((.(((((((((((((((.((((((.(.(....).).)))))).))))))))))))))).))))...))))))).

Structure

c       guug    C               G      u g g 
 gggguug    uuaU UUUGGUUAUCUAGCU UAUGAg g u u
 |||||||    |||| ||||||||||||||| |||||| | |  
 ccccaau    aaUG AAGCCAAUAGAUCGA AUAcuu u a g
a       -aaa    A               A      c g g 

Annotation confidence High

Genome context

chr1: 156420341-156420429 [-]

Disease association

hsa-mir-9-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-9-5p

• Accession: MIMAT0000441
• Description: Homo sapiens hsa-miR-9-5p mature miRNA
• Sequence: 16 - UCUUUGGUUAUCUAGCUGUAUGA - 38
• Evidence: experimental ; cloned [2]

Mature hsa-miR-9-3p

• Accession: MIMAT0000442
• Description: Homo sapiens hsa-miR-9-3p mature miRNA
• Sequence: 55 - AUAAAGCUAGAUAACCGAAAGU - 76
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739