Stem-loop hsa-mir-142

Accession

MI0000458

Symbol

HGNC: MIR142

Description

Homo sapiens hsa-mir-142 precursor miRNA mir-142

Gene
family

RF01896; mir-142

Literature search

284 open access papers mention hsa-mir-142
(1956 sentences)

Sequence

381593 reads, 2448 reads per million, 132 experiments

gacagugcagucaccCAUAAAGUAGAAAGCACUACUaacagcacuggagggUGUAGUGUUUCCUACUUUAUGGAugaguguacugug
.((((((((.(((.(((((((((((.(((((((((...(..(....)..)..))))))))).))))))))))).))).)))))))).

Structure

g        g   c           A         Uaa ag a 
 acagugca uca cCAUAAAGUAG AAGCACUAC   c  c c
 |||||||| ||| ||||||||||| |||||||||   |  |  
 ugucaugu agu GGUAUUUCAUC UUUGUGAUG   g  g u
g        g   A           C         -Ug ga g 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Michael et al. verified the expression of a sequence from the 3' arm of this stem-loop (named miR-142-3p here) [2], and both miR-142-5p (from the 5' arm) and miR-142-3p ware later detected in human HL-60 leukemia cells [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr17: 58331232-58331318 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-142

Disease association

hsa-mir-142 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-142-5p

• Accession: MIMAT0000433
• Description: Homo sapiens hsa-miR-142-5p mature miRNA
• Sequence: 16 - CAUAAAGUAGAAAGCACUACU - 36
• Evidence: experimental ; cloned [3-4]

Mature hsa-miR-142-3p

• Accession: MIMAT0000434
• Description: Homo sapiens hsa-miR-142-3p mature miRNA
• Sequence: 52 - UGUAGUGUUUCCUACUUUAUGGA - 74
• Evidence: experimental ; cloned [2-4]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 15325244
   Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
   "Kasashima K, Nakamura Y, Kozu T"
   "Biochem Biophys Res Commun (2004) 322:403-410


3. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


4. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739