Accession
MI0000454
Symbol
HGNC:
MIR137
Description
Homo sapiens
hsa-mir-137 precursor miRNA mir-137
Gene
family?
family?
RF00694;
mir-137
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR137 is a microRNA implicated in various biological processes and has been associated with neurological functions and disorders [PMC7237267]. In neurons with a conditional knockout (cKO) of MIR137, treatment with VU0240551 has been shown to adjust the maximum peak outward potassium amplitude to levels comparable to wild-type (WT) neurons, which may suggest a potential compensatory mechanism or therapeutic target [PMC7237267]. However, while the methylation status of MIR137 has been studied in the context of cancer, the specific link to the progression of non-small-cell lung cancer requires further clarification, as the evidence does not conclusively attribute this association to MIR137 alone without considering other factors [PMC4626561].
Literature search
199 open access papers mention hsa-mir-137
(1747 sentences)
(1747 sentences)
Sequence
102896
reads,
1706
reads per million, 71 experiments
gguccucugacucucuucggugACGGGUAUUCUUGGGUGGAUAAUacggauuacguugUUAUUGCUUAAGAAUACGCGUAGucgaggagaguaccagcggca
.(.((.((((((((((((((..(((.(((((((((((((.((((((((.....)).))))))))))))))))))).)))..)))))))))))..))).))).
.(.((.((((((((((((((..(((.(((((((((((((.((((((((.....)).))))))))))))))))))).)))..)))))))))))..))).))).
Structure
g u u -- ug G G - g g cc cug acucucuucgg ACG GUAUUCUUGGGUG AUAAUa cg a | || ||| ||||||||||| ||| ||||||||||||| |||||| || u c gg gac ugagaggagcu UGC CAUAAGAAUUCGU UAUUgu gc u a - c ca GA G - u a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].
Genome context
chr1: 98046070-98046171 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-137
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-137 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-137 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-137 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-137-3p
| Accession | MIMAT0000429 |
| Description | Homo sapiens hsa-miR-137-3p mature miRNA |
| Sequence | 59 - UUAUUGCUUAAGAAUACGCGUAG - 81 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-137-5p
| Accession | MIMAT0037310 |
| Description | Homo sapiens hsa-miR-137-5p mature miRNA |
| Sequence | 23 - ACGGGUAUUCUUGGGUGGAUAAU - 45 |
| Evidence | not_experimental |
References
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