Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR128-1 is a microRNA gene that interacts with the CDH1 coding protein cadherin through a specific upstream protein called Bmi1, which is the direct target of MIR128-1 [PMC5320387]. MIR128-1 is part of a gene family that includes MIR128-2, and both genes encode different species of microRNAs [PMC5481840]. Specifically, MIR128-1 and MIR128-2 encode miR-128-3p species with identical mature sequences. Additionally, MIR128-1 encodes miR-128-1-5p species, while MIR128-2 encodes miR-128-2-p5 species. These two species differ slightly in their sequences [PMC5481840].
MicroRNAs are small non-coding RNA molecules that play important roles in gene regulation and are involved in various biological processes [PMC5320387]. The interaction between MIR128-1 and CDH1 through Bmi1 suggests a potential regulatory mechanism for cadherin expression mediated by microRNAs [PMC5320387]. The presence of different mature sequences encoded by the MIR128 genes suggests potential functional differences between the miR-p5 and miR-p3p species [PMC5481840].
Overall, these findings highlight the complexity of microRNA regulation and provide insights into the specific interactions between microRNAs and their target proteins. Further research is needed to fully understand the functional significance of these interactions in gene regulation processes.
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The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical . The sequences are therefore renamed mir-128-1 and mir-128-2.