Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR124-3 is a conserved microRNA that has been found to inhibit invasion and migration of malignant cells in ovarian cancer and hepatocellular cancer [PMC6712160]. It is one of three members of the Mir124 class, along with Mir124-1 and Mir124-2, located at different genomic positions [PMC6346295]. MIR124-3 has been shown to be hypermethylated in tumor samples, with a 16-fold difference in methylation compared to control samples [PMC8656781]. Hypermethylation of MIR124-3 has also been associated with shorter overall survival in ovarian cancer patients [PMC8835734]. Methylation levels of MIR124-3 have been found to increase significantly in primary ovarian tumors and peritoneal macroscopic metastases compared to control samples [PMC8835734]. Additionally, MIR124-3 methylation has been associated with the onset of ovarian cancer pathogenesis [PMC8835734]. MIR124-3 is one of three genes that encode the same mature miR-124, with the other two genes being MIR124-1 and MIR124-2 [PMC4861808]. It has also been found to be methylated in patients with borderline personality disorder (BPD) [PMC6252387] and is involved in neurogenesis [PMC7686352]. Furthermore, MIR124-3 is one of four microRNA genes identified as having anti-tumor roles in pancreatic ductal adenocarcinoma (PDAC) [PMC9599555]. CpG islands located in the promoters of all three miR-124 precursor genes (MIR124-1, MIR124-2, and MIR 24 - 3) have been selected for analysis due to specific criteria being met. However, it remains unclear whether the upregulation of miR-124 is directly related to the hypomethylation of the precursor genes [PMC8724533].
u - c gC A GA uaaug
gagg gcc cucu GUGUUCAC GCG CCUUGAUu u
|||| ||| |||| |||||||| ||| ||||||||
cucc cgg gagA CGUAAGUG CGC GGAAUuaa c
c g a AC G AC cauau
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miR-124 was first identified by cloning studies in mouse . Its expression was later verified in human embryonic stem cells . The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.