Accession
MI0000444
Symbol
HGNC:
MIR124-2
Description
Homo sapiens
hsa-mir-124-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR124-2 is a genomic locus that is subject to methylation, a process that can regulate gene expression [PMC5338782]. In the context of human papillomavirus (HPV) DNA testing, the methylation status of MIR124-2, along with FAM19A4, is assessed using the QIAsure Methylation Test [PMC10095339]. This testing is conducted at the time of enrollment for individuals being screened for HPV [PMC10095339]. Notably, MIR124-2 has been identified as the locus with the highest frequency of methylation in follow-up specimens as well, suggesting its potential importance in monitoring HPV-related changes over time [PMC5338782].
Literature search
428 open access papers mention hsa-mir-124-2
(3661 sentences)
(3661 sentences)
Sequence
97976
reads,
932
reads per million, 65 experiments
aucaagauuagaggcucugcucucCGUGUUCACAGCGGACCUUGAUuuaaugucauacaauUAAGGCACGCGGUGAAUGCCAAgagcggagccuacggcugcacuugaa
.(((((..(((((((((((((((..((((((((.(((..((((((((...........))))))))..))).))))))))..))))))))))))....)))..))))).
.(((((..(((((((((((((((..((((((((.(((..((((((((...........))))))))..))).))))))))..))))))))))))....)))..))))).
Structure
a au ---- cC A GA uaau ucaag uag aggcucugcucu GUGUUCAC GCG CCUUGAUu g ||||| ||| |||||||||||| |||||||| ||| |||||||| u aguuc guc uccgaggcgagA CGUAAGUG CGC GGAAUuaa c a ac ggca AC G AC caua
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-124 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chr8: 64379149-64379257 [+]
Disease association
hsa-mir-124-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-124-5p
| Accession | MIMAT0004591 |
| Description | Homo sapiens hsa-miR-124-5p mature miRNA |
| Sequence | 25 - CGUGUUCACAGCGGACCUUGAU - 46 |
| Evidence |
experimental
cloned [5] |
Mature hsa-miR-124-3p
| Accession | MIMAT0000422 |
| Description | Homo sapiens hsa-miR-124-3p mature miRNA |
| Sequence | 62 - UAAGGCACGCGGUGAAUGCCAA - 83 |
| Evidence |
experimental
cloned [2,4-5] |
| Database links |
|
| Predicted targets |
|
References
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