Stem-loop hsa-mir-122

Accession

MI0000442

Symbol

HGNC: MIR122

Description

Homo sapiens hsa-mir-122 precursor miRNA mir-122

Gene
family

RF00684; mir-122

Literature search

562 open access papers mention hsa-mir-122
(3998 sentences)

Sequence

325187 reads, 1643 reads per million, 69 experiments

ccuuagcagagcugUGGAGUGUGACAAUGGUGUUUGugucuaaacuaucaAACGCCAUUAUCACACUAAAUAgcuacugcuaggc
.((((((((((((((..(((((((.(((((((((((............))))))))))).)))))))..)))))).)))))))).

Structure

c        -      GG       C           ugucu 
 cuuagcag agcugU  AGUGUGA AAUGGUGUUUG     a
 |||||||| ||||||  ||||||| |||||||||||      
 ggaucguc ucgAUA  UCACACU UUACCGCAAac     a
c        a      AA       A           uauca 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr18: 58451074-58451158 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-122

Disease association

hsa-mir-122 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-122-5p

• Accession: MIMAT0000421
• Description: Homo sapiens hsa-miR-122-5p mature miRNA
• Sequence: 15 - UGGAGUGUGACAAUGGUGUUUG - 36
• Evidence: experimental ; cloned [2-3], Northern [2]

Mature hsa-miR-122-3p

• Accession: MIMAT0004590
• Description: Homo sapiens hsa-miR-122-3p mature miRNA
• Sequence: 51 - AACGCCAUUAUCACACUAAAUA - 72
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739