Stem-loop hsa-mir-30b

Accession

MI0000441

Symbol

HGNC: MIR30B

Description

Homo sapiens hsa-mir-30b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR30B is a microRNA that has been studied for its role in cellular processes such as autophagy and apoptosis [PMC3429542; PMC5264595].'>PMC5264595].. The effect of MIR30B on autophagy was investigated under starvation conditions, but there is no specific mention of H. pylori in this context [PMC3429542]. Additionally, the transfection of cells with a MIR30B mimic has been shown to significantly increase the expression of pro-apoptotic genes CASP3 and APAF1 in certain breast cancer cell lines such as BT474 wt and BT474r [PMC5264595]. This effect, however, was not observed in HCC1954 cells, suggesting that MIR30B may have cell type-specific roles in regulating apoptosis-related genes [PMC5264595].

Literature search

398 open access papers mention hsa-mir-30b
(1810 sentences)

Sequence

147792 reads, 938 reads per million, 136 experiments

accaaguuucaguucaUGUAAACAUCCUACACUCAGCUguaauacauggauuggCUGGGAGGUGGAUGUUUACUUCagcugacuugga
.(((((..((((((...((((((((((.((.((((((((............))))))))..))))))))))))...))))))))))).

Structure

a     uu      caU          U  -A        uaaua 
 ccaag  ucaguu   GUAAACAUCC AC  CUCAGCUg     c
 |||||  ||||||   |||||||||| ||  ||||||||      
 gguuc  agucga   CAUUUGUAGG UG  GGGUCggu     a
a     --      CUU          -  GA        uaggu 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

chr8: 134800520-134800607 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-30b

Mature hsa-miR-30b-5p

• Accession: MIMAT0000420
• Description: Homo sapiens hsa-miR-30b-5p mature miRNA
• Sequence: 17 - UGUAAACAUCCUACACUCAGCU - 38
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-30b-3p

• Accession: MIMAT0004589
• Description: Homo sapiens hsa-miR-30b-3p mature miRNA
• Sequence: 55 - CUGGGAGGUGGAUGUUUACUUC - 76
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739