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MIR30B is a microRNA that has been studied in relation to its effect on autophagy. To determine if this effect is specific to H. pylori, researchers conducted a study where they detected MAP1LC3B-II conversion under starvation conditions [PMC3429542]. In normal conditions, transfection with either MIR30B or miR-26a mimic resulted in a significant increase in the expression of the pro-apoptotic CASP3 and APAF1 genes in BT474 wt and BT474r cells, but not in HCC1954 cells [PMC5264595]. The study found that MIR30B and miR-26a mimic increased CASP3 expression with p-values of 0.026 and 0.032 respectively for BT474 wt cells, and p-values of 0.034 and 0.019 respectively for BT474r cells [PMC5264595]. Similarly, MIR30B and miR-26a mimic increased APAF1 expression with p-values of 0.035 and 0.042 respectively for BT474 wt cells, and p-values of 0.041 and 0.034 respectively for BT474r cells [PMC5264595]. However, there was no significant increase in CASP3 or APAF1 expression observed in HCC1954 cells when transfected with either MIR30B or miR-26a mimic [PMC5264595]. These findings suggest that the effect of MIR30B on autophagy may be specific to certain cell types or conditions [PMC3429542] [PMC5264595].