Accession
MI0000300
Symbol
HGNC:
MIR223
Description
Homo sapiens
hsa-mir-223 precursor miRNA mir-223
Gene
family?
family?
RF00664;
mir-223
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR223 is a microRNA that plays a significant role in the regulation of immune responses and cellular processes. In MIR223 deficient mice, an increase in granulocyte numbers with an abnormal phenotype and spontaneous inflammatory lung pathology has been observed, indicating MIR223's role in neutrophil regulation [PMC7871001]. This microRNA is notably enriched in microglia, suggesting its importance in the central nervous system [PMC6351131]. MIR223 can also influence endothelial cell function by regulating the expression of its mRNA targets, FBXW7 and EFNA1, when derived from thrombin-activated platelet-derived extracellular vesicles [PMC8468534]. In systemic lupus erythematosus (SLE) patients with active nephritis, a significant decrease in peripheral plasma MIR223 expression has been reported [PMC7871001], while its levels are depleted in tissues during hepatocellular carcinoma (HCC) but increased in serum, proposing its potential as a serum biomarker for HCC [PMC4581219]. Additionally, MIR223 has been implicated as a key regulator of apoptosis and cell growth through FBXW7 and is considered as a reference miRNA for studies due to its deregulation impact on cellular processes such as tumor metabolism and apoptosis [PMC9495386], [PMC4558025]. Furthermore, it targets key components involved in miRNA-mediated synaptic plasticity regulation pathways within the brain [PMC4783348].
Literature search
400 open access papers mention hsa-mir-223
(2690 sentences)
(2690 sentences)
Sequence
106277
reads,
1820
reads per million, 97 experiments
ccuggccuccugcagugccacgcucCGUGUAUUUGACAAGCUGAGUUggacacuccaugugguagagUGUCAGUUUGUCAAAUACCCCAagugcggcacaugcuuaccag
.((((......((((((((.((((..(.((((((((((((((......(((((((.........))))))))))))))))))))).)..)))).))))).)))...))))
.((((......((((((((.((((..(.((((((((((((((......(((((((.........))))))))))))))))))))).)..)))).))))).)))...))))
Structure
c ccuccu - a cC U GAGUUg cau cugg gca gugcc cgcu G GUAUUUGACAAGCU gacacuc g |||| ||| ||||| |||| | |||||||||||||| ||||||| u gacc cgu cacgg guga C CAUAAACUGUUUGA CUGUgag g - ---auu a c AC C ------ aug
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chrX: 66018870-66018979 [+]
Disease association
hsa-mir-223 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-223-5p
| Accession | MIMAT0004570 |
| Description | Homo sapiens hsa-miR-223-5p mature miRNA |
| Sequence | 26 - CGUGUAUUUGACAAGCUGAGUU - 47 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-223-3p
| Accession | MIMAT0000280 |
| Description | Homo sapiens hsa-miR-223-3p mature miRNA |
| Sequence | 68 - UGUCAGUUUGUCAAAUACCCCA - 89 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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