Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR222 is a microRNA that has been studied in various contexts [PMC8762293]. Lentivirus-mediated transfer of the MIR222 gene has been shown to promote adipogenesis in 3T3-L1 cells, as evidenced by the up-regulation of C/EBPα and PPARγ [PMC8762293]. Additionally, the post-transcriptional interaction between MIR222 and SCD5, as well as the transcriptional regulation of MEF2C by MIR222, have been validated through in vitro and in vivo assays [PMC7584575]. Furthermore, angiotensin-2 has been found to regulate a long nonprotein-coding RNA called lncAng362, which is responsible for the production of two microRNAs involved in vascular smooth muscle cell proliferation: miR221 and MIR222 [PMC7123062]. Finally, miR21, miR124, and MIR222 have been analyzed for their expression in both small extracellular vesicles (sEVs) and medium/large extracellular vesicles (m/lEVs) [PMC10056600]. These findings highlight the diverse functions of MIR222 across various biological processes.
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This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences . Expression of the excised miR was validated in zebrafish, and the ends mapped by cloning. Subsequent cloning studies have also verified the expression of miR-222 in human ES cells. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .