Accession
MI0000299
Symbol
HGNC:
MIR222
Description
Homo sapiens
hsa-mir-222 precursor miRNA mir-221
Gene
family?
family?
RF00651;
mir-221
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR222 is a microRNA implicated in various cellular processes, including adipogenesis and vascular smooth muscle cell (vSMC) proliferation [PMC8762293; PMC7123062].'>PMC7123062].. In 3T3-L1 cells, the lentivirus-mediated introduction of the MIR222 gene was shown to enhance adipogenesis, as evidenced by the increased expression of key adipogenic transcription factors C/EBPα and PPARγ [PMC8762293]. Further research has established a post-transcriptional interaction between MIR222 and stearoyl-CoA desaturase 5 (SCD5), as well as MIR222's role in the transcriptional regulation of myocyte enhancer factor 2C (MEF2C), through both in vitro and in vivo studies [PMC7584575]. Additionally, MIR222, along with miR221, is regulated by angiotensin-2 through its effect on the long non-coding RNA lncAng362; both microRNAs are associated with vSMC proliferation [PMC7123062]. The expression levels of MIR222 have also been analyzed in small extracellular vesicles (sEVs) and medium/large extracellular vesicles (m/lEVs), highlighting its presence across different extracellular compartments [PMC10056600].
Literature search
396 open access papers mention hsa-mir-222
(2020 sentences)
(2020 sentences)
Sequence
1155220
reads,
4867
reads per million, 157 experiments
gcugcuggaagguguagguacccucaauggCUCAGUAGCCAGUGUAGAUCCUgucuuucguaaucagcAGCUACAUCUGGCUACUGGGUcucugauggcaucuucuagcu
...(((((((((((......((.(((..(((((((((((((((((((...(((...........)))...))))).))))))))))))))..))).))))))))))))).
...(((((((((((......((.(((..(((((((((((((((((((...(((...........)))...))))).))))))))))))))..))).))))))))))))).
Structure
gcu uaggua c au - AUC ucuu gcuggaaggug cc uca ggCUCAGUAGCCAG UGUAG CUg u ||||||||||| || ||| |||||||||||||| ||||| ||| c cgaucuucuac gg agu cUGGGUCAUCGGUC ACAUC gac g --u ------ u cu U GAc uaau
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR was validated in zebrafish, and the ends mapped by cloning. Subsequent cloning studies have also verified the expression of miR-222 in human ES cells. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chrX: 45747015-45747124 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-222
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-222 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-222-5p
| Accession | MIMAT0004569 |
| Description | Homo sapiens hsa-miR-222-5p mature miRNA |
| Sequence | 31 - CUCAGUAGCCAGUGUAGAUCCU - 52 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-222-3p
| Accession | MIMAT0000279 |
| Description | Homo sapiens hsa-miR-222-3p mature miRNA |
| Sequence | 69 - AGCUACAUCUGGCUACUGGGU - 89 |
| Evidence |
experimental
cloned [2-5], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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