Accession
MI0000298
Symbol
HGNC:
MIR221
Description
Homo sapiens
hsa-mir-221 precursor miRNA mir-221
Gene
family?
family?
RF00651;
mir-221
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR221, a microRNA, has been implicated in various cellular processes, including apoptosis and autophagy, as well as in the pathogenesis of multiple hyperlipidemia-related diseases (HRDs) and cancer [PMC7318537; PMC8436230;'>PMC8436230; PMC7604447; PMC4389881].'>PMC4389881].. Inhibition of MIR221 has been shown to increase apoptosis in transfected cells [PMC7318537]. Moreover, MIR221 appears to be involved in the regulation of autophagic flux, as evidenced by the aggregation of P62 in cells transfected with MIR221 mimics [PMC8436230]. In the context of atherosclerosis and vascular calcification, MIR221 is one among several miRNAs whose expression levels are altered [PMC6683928]. Additionally, MIR221 has been identified as an oncomiR that can promote cancer cell growth by targeting PTEN expression and activating oncogenic pathways such as PI3K/Akt/mTOR [PMC4389881; PMC8071157].. The expression level of MIR221 can be normalized to U6 RNA for analytical purposes [PMC8327461], and its levels along with other clinical features can be used to predict patient outcomes in diseases such as hyperlipidemia-related liver cancer associated with cholangiocarcinoma (HL-CCA) using statistical models like SPSS software [PMC7075433].
Literature search
572 open access papers mention hsa-mir-221
(4115 sentences)
(4115 sentences)
Sequence
1352665
reads,
5088
reads per million, 157 experiments
ugaacauccaggucuggggcaugaACCUGGCAUACAAUGUAGAUUUcuguguucguuaggcaacAGCUACAUUGUCUGCUGGGUUUCaggcuaccuggaaacauguucuc
.((((((((((((....(((.(((((((((((.(((((((((....(((((((.....))).))))))))))))).))))))).)))).))))))))))....)))))..
.((((((((((((....(((.(((((((((((.(((((((((....(((((((.....))).))))))))))))).))))))).)))).))))))))))....)))))..
Structure
-u ---- cugg a - U AUUU - c gaaca uccaggu ggc ugaA CCUGGCA ACAAUGUAG cugu guu g ||||| ||||||| ||| |||| ||||||| ||||||||| |||| ||| u cuugu aggucca ucg aCUU GGGUCGU UGUUACAUC GAca cgg u cu acaa ---- g U C ---- a a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and later validated in human HL-60 leukemia cells [2].
Genome context
chrX: 45746157-45746266 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-221
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-221 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-221-5p
| Accession | MIMAT0004568 |
| Description | Homo sapiens hsa-miR-221-5p mature miRNA |
| Sequence | 25 - ACCUGGCAUACAAUGUAGAUUU - 46 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-221-3p
| Accession | MIMAT0000278 |
| Description | Homo sapiens hsa-miR-221-3p mature miRNA |
| Sequence | 65 - AGCUACAUUGUCUGCUGGGUUUC - 87 |
| Evidence |
experimental
cloned [2-4], Illumina [5] |
| Database links |
|
| Predicted targets |
|
References
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