Accession
MI0000293
Symbol
HGNC:
MIR217
Description
Homo sapiens
hsa-mir-217 precursor miRNA mir-217
Gene
family?
family?
RF00673;
mir-217
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR217 is a microRNA that has been observed to have varying expression levels in different biological contexts and disease states. In kidney renal papillary cell carcinoma (KIRP), MIR217, along with IGF2BP3 and NCAPG, showed higher expression in type 2 compared to type 1, suggesting a potential role in tumor differentiation or progression [PMC7744790]. In cancer studies, MIR217 has been implicated in the suppression of pulmonary metastasis when expressed in 6DT1 cells, although it did not significantly affect the primary tumor growth [PMC3912413]. Furthermore, MIR217 is known to downregulate SIRT1 mRNA and protein levels, which may contribute to vascular endothelial aging by weakening the antioxidant capacity [PMC9513221]. The interactions of MIR217 with other cellular components have been explored; for instance, its relationship with LINC01268 and SOS1 was investigated to understand its effects on cell viability, cycle progression, and apoptosis in acute myeloid leukemia (AML) cells [PMC7326380]. Additionally, MIR217 is known to interact with long non-coding RNA MALAT1 which can affect the regulatory interactions between miRNAs and mRNAs [PMC6351443]. In inflammatory conditions induced by TNBS (2,4,6-trinitrobenzenesulfonic acid), the expression of MIR217 was significantly downregulated; however, this effect was reversed by BEY-treatment which upregulated its expression [PMC9101272].
Literature search
100 open access papers mention hsa-mir-217
(638 sentences)
(638 sentences)
Sequence
8853
reads,
248
reads per million, 44 experiments
aguauaauuauuacauaguuuuugaugucgcagaUACUGCAUCAGGAACUGAUUGGAuaagaaucagucacCAUCAGUUCCUAAUGCAUUGCCuucagcaucuaaacaag
.(((.......)))...((((..(((((.(.((.((.(((((.((((((((((.((((........))).).)))))))))).))))).)).)).).))))).))))...
.(((.......)))...((((..(((((.(.((.((.(((((.((((((((((.((((........))).).)))))))))).))))).)).)).).))))).))))...
Structure
aguauaauuauuacaua uu c c a C C U - aag
guuu gaugu g ag UA UGCAU AGGAACUGAU G GAu a
|||| ||||| | || || ||||| |||||||||| | |||
caaa cuacg c uC GU ACGUA UCCUUGACUA c cug a
--------------gaa -u a u C U A C a acu
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr2: 55982967-55983076 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-217
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-217 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-217-5p
| Accession | MIMAT0000274 |
| Description | Homo sapiens hsa-miR-217-5p mature miRNA |
| Sequence | 35 - UACUGCAUCAGGAACUGAUUGGA - 57 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-217-3p
| Accession | MIMAT0037308 |
| Description | Homo sapiens hsa-miR-217-3p mature miRNA |
| Sequence | 72 - CAUCAGUUCCUAAUGCAUUGCC - 93 |
| Evidence | not_experimental |
References
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