miRBase entry: hsa-mir-215

Stem-loop hsa-mir-215

Homo sapiens hsa-mir-215 precursor miRNA
Gene family
MIPF0000063; mir-192

Caution, this is an AI generated summary based on literature. This may have errors. ?

Hsa-mir-215 is a microRNA (miRNA) that has been studied in various contexts. It has been identified as one of the miRNAs with 20 or fewer validated targets in miRTarBase, along with hsa-miR-21-5p and hsa-miR-124-3p [PMC5484592]. In certain studies, hsa-mir-215 has been found to be significantly associated with target genes involved in specific pathways [PMC8876010]. It has also been suggested as a potential prognostic indicator for chemotherapeutic benefits in STS metastasis [PMC4434893]. In the context of colorectal cancer (CRC), hsa-mir-215 has shown associations with disease stage and CRC-specific mortality [PMC6007480]. Additionally, hsa-mir-215 has been found to be upregulated in NPM1 mutated AML compared to NPM1 wild-type AML [PMC7851519]. It is worth noting that hsa-mir-215 exhibits a high correlation with Esophageal Neoplasms [PMC6929455]. In tumor tissues, the expression of hsa-mir-215 is significantly lower compared to adjacent normal colon epithelial tissue [PMC8798538]. Furthermore, it has been identified as one of the miRNAs involved in specific molecular mechanisms, acting as a direct inhibitor for certain targets [PMC8233096]. In different studies, it was found to be both upregulated and downregulated depending on the context and disease type.

Literature search
102 open access papers mention hsa-mir-215
(417 sentences)


21962 reads, 146 reads per million, 86 experiments

aucauucagaa     -        aaA  A    -U   U          uaua 
           auggu auacagga   UG CCUA  GAA UGACAGACaa    g
           ||||| ||||||||   || ||||  ||| ||||||||||    c
           uguca uaugucuu   AC GGAU  CUU ACUGUCUguu    u
-aacuucaucg     g        AUA  C    UU   U          ugag 

Annotation confidence Not enough data
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2].

Genome context
chr1: 220117853-220117962 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-215
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-215 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-215 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-215 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-215-5p

Accession MIMAT0000272
Description Homo sapiens hsa-miR-215-5p mature miRNA
Evidence experimental
cloned [2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-215-3p

Accession MIMAT0026476
Description Homo sapiens hsa-miR-215-3p mature miRNA
Evidence experimental
Illumina [3]


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45