Accession
MI0000290
Symbol
HGNC:
MIR214
Description
Homo sapiens
hsa-mir-214 precursor miRNA mir-214
Gene
family?
family?
RF00660;
mir-214
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR214 is a microRNA that has been implicated in the process of endothelial injury when induced by oxidized low-density lipoprotein (oxLDL) [PMC9199460]. It is suggested that the inhibition of MIR214, among other microRNAs, might confer protective effects against such endothelial damage [PMC9199460]. Additionally, MIR214 is located in a novel genomic region identified as 1q24.3, which has been associated with gene-based genome-wide significant signals [PMC5458088]. This region also includes DNM3OS and MIR3120, indicating a potential cluster of functionally related genes that could be relevant to endothelial function or pathology [PMC5458088].
Literature search
289 open access papers mention hsa-mir-214
(2846 sentences)
(2846 sentences)
Sequence
58209
reads,
943
reads per million, 111 experiments
ggccuggcuggacagaguugucaugugucUGCCUGUCUACACUUGCUGUGCagaacauccgcucaccuguACAGCAGGCACAGACAGGCAGUcacaugacaacccagccu
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).
Structure
ggccu acaga u ACA aacau
ggcugg guugucaugug cUGCCUGUCU CUUGCUGUGCag c
|||||| ||||||||||| |||||||||| |||||||||||| c
ccgacc caacaguacac GACGGACAGA GGACGACAuguc g
----u ----- U CAC cacuc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr1: 172138798-172138907 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-214
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-214 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-214 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-214 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-214-5p
| Accession | MIMAT0004564 |
| Description | Homo sapiens hsa-miR-214-5p mature miRNA |
| Sequence | 30 - UGCCUGUCUACACUUGCUGUGC - 51 |
| Evidence |
experimental
cloned [2-3], Northern [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-214-3p
| Accession | MIMAT0000271 |
| Description | Homo sapiens hsa-miR-214-3p mature miRNA |
| Sequence | 71 - ACAGCAGGCACAGACAGGCAGU - 92 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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