miRBase entry: hsa-mir-214

Stem-loop hsa-mir-214

Homo sapiens hsa-mir-214 precursor miRNA
Gene family
MIPF0000062; mir-214

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR214 is a microRNA that has been reported to increase in the oxLDL-induced model, suggesting its potential role in endothelial injury [PMC9199460]. In addition to MIR214, miR-106 is another microRNA that has been found to increase in the same model [PMC9199460]. Inhibition of these molecules could potentially protect against endothelial injury [PMC9199460]. Furthermore, there are six gene-based genome-wide significant association signals at three novel genomic regions: 1q24.3 (DNM3OS, MIR214, and MIR3120), 9q22.32 (MIR23B and MIR27B), and 16p13.3 (LINC00921) [PMC5458088]. These regions are associated with various genetic factors that may play a role in different biological processes or diseases [PMC5458088]. Overall, understanding the functions and regulation of microRNAs like MIR214 can provide insights into their potential therapeutic applications in protecting against endothelial injury or other related conditions.

Literature search
289 open access papers mention hsa-mir-214
(2846 sentences)


58209 reads, 943 reads per million, 111 experiments

ggccu      acaga           u          ACA            aacau 
     ggcugg     guugucaugug cUGCCUGUCU   CUUGCUGUGCag     c
     ||||||     ||||||||||| ||||||||||   ||||||||||||     c
     ccgacc     caacaguacac GACGGACAGA   GGACGACAuguc     g
----u      -----           U          CAC            cacuc 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr1: 172138798-172138907 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-214
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-214 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-214 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-214 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-214-5p

Accession MIMAT0004564
Description Homo sapiens hsa-miR-214-5p mature miRNA
Evidence experimental
cloned [2-3], Northern [3]
Database links
Predicted targets

Mature hsa-miR-214-3p

Accession MIMAT0000271
Description Homo sapiens hsa-miR-214-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540

  3. PubMed ID: 18230126
    New miRNAs cloned from neuroblastoma
    "Afanasyeva EA, Hotz-Wagenblatt A, Glatting KH, Westermann F"
    "BMC Genomics (2008) 9:52