miRBase entry: hsa-mir-212

Stem-loop hsa-mir-212

Homo sapiens hsa-mir-212 precursor miRNA
Gene family
MIPF0000065; mir-132

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR212 is a microRNA that has been studied for its effects on the proliferation and apoptosis of ovarian cancer (OC) cell lines [PMC6995389]. In a meta-analysis of Series 1 6 and 10-month data, as well as human BA9 data, eight microRNAs (Mir615, Mir135b, MIR212, Mir132, Mir20a, Mir708, Mir99a, Mir138-2) were found to be significantly associated with CAG length [PMC5764268]. These microRNAs passed the p-value threshold of 0.05 and had a false discovery rate (FDR) less than 0.05 [PMC5764268]. The specific role of MIR212 in this association was not mentioned in the given context. However, it is worth noting that MIR212 has been previously implicated in various biological processes and diseases. For example, it has been shown to be involved in the regulation of cell proliferation and apoptosis in different cancer types [PMC6995389]. Additionally, MIR212 has been associated with neurodegenerative diseases such as Alzheimer's disease [PMC5764268]. Further research is needed to fully understand the role of MIR212 in OC cell lines and its association with CAG length.

Literature search
129 open access papers mention hsa-mir-212
(875 sentences)


8023 reads, 228 reads per million, 89 experiments

--      accccgcccgga   c   c   -cA  U     CU      C      ccc   c 
  cggggc            cag gcg cgg   CC UGGCU  AGACUG UUACUg   ggg  
  ||||||            ||| ||| |||   || |||||  |||||| ||||||   ||| c
  gccccg            guc cgc gcc   GG ACUGA  UCUGAC AAUgac   ccc  
cc      ------------   -   a   aCC  C     CC      -      --u   g 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. The 3' end was not experimentally determined. The sequence maps to human chromosome 17, but its expression has not been experimentally verified in human.

Genome context
chr17: 2050271-2050380 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-212
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-212 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-212-3p

Accession MIMAT0000269
Description Homo sapiens hsa-miR-212-3p mature miRNA
Evidence not_experimental
Database links
Predicted targets

Mature hsa-miR-212-5p

Accession MIMAT0022695
Description Homo sapiens hsa-miR-212-5p mature miRNA
Evidence not_experimental
Database links
Predicted targets


  1. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540