Accession
MI0000287
Symbol
HGNC:
MIR211
Description
Homo sapiens
hsa-mir-211 precursor miRNA mir-204
Gene
family?
family?
RF00646;
mir-204
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR211 is a cellular microRNA that has been implicated in the regulation of cell cycle progression in human osteosarcoma cells, where its overexpression has been observed to increase the percentage of cells in the G0/G1 phase and decrease the percentage in the S phase [PMC6617937]. This microRNA, along with others such as miR28, miR29b, miR138, and miR326, was selected for study due to its potential complementary target sequence within the HIV-1 genome [PMC3256098]. Additionally, MIR211 is known to be upregulated in various tumors including gliomas; however, its downregulation has been associated with increased sensitivity of glioma cells to temozolomide (TMZ), a chemotherapeutic agent [PMC7732422].
Literature search
96 open access papers mention hsa-mir-211
(799 sentences)
(799 sentences)
Sequence
47750
reads,
1763
reads per million, 51 experiments
ucaccuggccaugugacuugugggcUUCCCUUUGUCAUCCUUCGCCUagggcucugagcaggGCAGGGACAGCAAAGGGGUGCucaguugucacuucccacagcacggag
.....(((....(((((...(((((.(((((((((..(((((.((((...(((...))).)))))))))..))))))))).)))))...)))))...)))..........
.....(((....(((((...(((((.(((((((((..(((((.((((...(((...))).)))))))))..))))))))).)))))...)))))...)))..........
Structure
-----ucacc ccau uug U CA C agg c
ugg gugac ugggc UCCCUUUGU UCCUU GCCU gcu
||| ||||| ||||| ||||||||| ||||| |||| ||| u
acc cacug acuCG GGGGAAACG AGGGA CGgg cga
gaggcacgac -cuu uug U AC - --a g
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. The sequence maps to human chromosome 15.
Genome context
chr15: 31065032-31065141 [-]
Disease association
hsa-mir-211 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-211-5p
| Accession | MIMAT0000268 |
| Description | Homo sapiens hsa-miR-211-5p mature miRNA |
| Sequence | 26 - UUCCCUUUGUCAUCCUUCGCCU - 47 |
| Evidence | not_experimental |
| Database links |
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| Predicted targets |
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Mature hsa-miR-211-3p
| Accession | MIMAT0022694 |
| Description | Homo sapiens hsa-miR-211-3p mature miRNA |
| Sequence | 63 - GCAGGGACAGCAAAGGGGUGC - 83 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
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References
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