Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR211 is a cellular miRNA that has been found to be upregulated in various types of tumors, particularly in gliomas. Conversely, the downregulation of MIR211 can increase the sensitivity of glioma cells to temozolomide (TMZ) [PMC7732422]. In a study, it was observed that both MIR211 overexpression and EZRIN siRNA transfection led to an increase in the percentage of cells in the G0/G1 phase and a decrease in the percentage of cells in the S phase in human osteosarcoma cells [PMC6617937]. This suggests that MIR211 may play a role in cell cycle regulation. Additionally, MIR211 was selected as one of five cellular miRNAs for further investigation due to its potential complementary target sequence in the HIV-1 genome [PMC3256098]. The HIV-1 Nef gene is known to be dispensable for viral replication in cultured human cells [PMC3256098]. Overall, these findings highlight the potential significance of MIR211 as a regulator of cell cycle progression and its potential role in HIV-1 infection.
-----ucacc ccau uug U CA C agg c
ugg gugac ugggc UCCCUUUGU UCCUU GCCU gcu
||| ||||| ||||| ||||||||| ||||| |||| ||| u
acc cacug acuCG GGGGAAACG AGGGA CGgg cga
gaggcacgac -cuu uug U AC - --a g
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This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences . Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. The sequence maps to human chromosome 15.