Accession
MI0000285
Symbol
HGNC:
MIR205
Description
Homo sapiens
hsa-mir-205 precursor miRNA mir-205
Gene
family?
family?
RF00656;
mir-205
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR205, identified as a microRNA, plays a role in the epithelial-mesenchymal transition (EMT) process by downregulating several markers associated with this process, including CD44, TAZ, E2A.E12, Twist, Snail-1, and CK5 [PMC5705145]. Additionally, PRKCE is highlighted as one of the six target genes of MIR205 [PMC4052696]. The microRNA spectrum including MIR205 also encompasses miR488*, miR125, mir185, miR1 and miR31 [PMC4742123]. Furthermore, MIR205 is part of a panel of microRNAs that includes miR16, miR200c, miR21, miR221 and miR34a which have been demonstrated to have predictive value in tumor presence with an area under the curve (AUC) statistic of 0.85 [PMC4815774].
Literature search
320 open access papers mention hsa-mir-205
(1811 sentences)
(1811 sentences)
Sequence
643348
reads,
3938
reads per million, 135 experiments
aaagauccucagacaauccaugugcuucucuugUCCUUCAUUCCACCGGAGUCUGucucauacccaaccaGAUUUCAGUGGAGUGAAGUUCaggaggcauggagcugaca
........((((.(..(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))))))))..
........((((.(..(((((((....((((((..(((((((((((.((((((((.............)))))))).)))))))))))..))))))))))))))))))..
Structure
aaagaucc a aa gcuu UC C ucuca
ucag c uccaugu cucuug CUUCAUUCCAC GGAGUCUG u
|||| | ||||||| |||||| ||||||||||| |||||||| a
aguc g agguacg gaggaC GAAGUGAGGUG CUUUAGac c
------ac - -- ---- UU A caacc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].
Genome context
chr1: 209432133-209432242 [+]
Disease association
hsa-mir-205 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-205 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-205 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-205-5p
| Accession | MIMAT0000266 |
| Description | Homo sapiens hsa-miR-205-5p mature miRNA |
| Sequence | 34 - UCCUUCAUUCCACCGGAGUCUG - 55 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-205-3p
| Accession | MIMAT0009197 |
| Description | Homo sapiens hsa-miR-205-3p mature miRNA |
| Sequence | 71 - GAUUUCAGUGGAGUGAAGUUC - 91 |
| Evidence |
experimental
454 [4] |
| Database links |
|
| Predicted targets |
|
References
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