miRBase entry: hsa-mir-204

Stem-loop hsa-mir-204

Homo sapiens hsa-mir-204 precursor miRNA
Gene family
MIPF0000042; mir-204

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR204 is a microRNA that has been studied in various contexts [PMC5627761]. In a study using a PLGA delivery system-functionalized titanium, it was found that the presence of PLGA with MIR204 inhibitor did not affect cell survival and proliferation, as indicated by the similar growth curve observed among different cell populations over a 4-day monitoring period [PMC5627761]. Additionally, histone modifications (HDA3) and miRNAs (miR29, MIR204, miR146a, and miR24) have been implicated in the development of anterior segment diseases such as Primary Open Angle Glaucoma [PMC4588317]. Furthermore, a study investigated the correlation between liver fat accumulation due to IDH2 deficiency and MIR204 in a high-fat diet. The results showed a correlation between liver fat accumulation and MIR204 levels as determined by the Pearson correlation coefficient [PMC9492679]. These findings highlight the potential role of MIR204 in various biological processes and diseases.

Literature search
191 open access papers mention hsa-mir-204
(1578 sentences)


23274 reads, 816 reads per million, 110 experiments

ggcua    cuuucuucau     ucg     U          A     U    gagaau 
     cagu          gugac   uggac UCCCUUUGUC UCCUA GCCU      a
     ||||          |||||   ||||| |||||||||| ||||| ||||      u
     guca          uacug   acuUG AGGGAAACGG AGGGU CGga      a
---cg    ---------c     uua     C          A     -    ggaagu 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].

Genome context
chr9: 70809975-70810084 [-]

Disease association
hsa-mir-204 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-204-5p

Accession MIMAT0000265
Description Homo sapiens hsa-miR-204-5p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-204-3p

Accession MIMAT0022693
Description Homo sapiens hsa-miR-204-3p mature miRNA
Evidence not_experimental
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540