Accession
MI0000283
Symbol
HGNC:
MIR203A
Description
Homo sapiens
hsa-mir-203a precursor miRNA mir-203
Gene
family?
family?
RF00696;
mir-203
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR203A is a microRNA whose expression is crucial for maintaining the epithelial phenotype, and its low expression levels have been observed in the A2780 cell line, which were not significantly altered by estrogen treatments [PMC7766742, PMC7308478].. The hypermethylation of the MIR203A gene is proposed as a potential marker for predicting metastasis in ovarian cancer (OvCa), indicating its significance in cancer progression [PMC8835734]. The genomic location of MIR203A is identified on chromosome 14, which suggests its distinct regulatory region compared to other microRNAs in the MIR200 family [PMC7766742]. In advanced-stage IV OvCa patients, MIR203A is one of six microRNAs found to have altered expression levels [PMC9599289]. The study aimed to explore the dependency of estrogen receptor alpha (ERα) on the expression of miR200s and MIR203A, highlighting the potential hormonal regulation of these microRNAs [PMC7766742].
Literature search
297 open access papers mention hsa-mir-203a
(2724 sentences)
(2724 sentences)
Sequence
49652
reads,
725
reads per million, 128 experiments
guguuggggacucgcgcgcuggguccAGUGGUUCUUAACAGUUCAACAGUUcuguagcgcaauuGUGAAAUGUUUAGGACCACUAGacccggcgggcgcggcgacagcga
.(((((..(.(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).)..))))).
.(((((..(.(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).)..))))).
Structure
g gg a u g c U G A - ug uguug g c cgc cgcuggguc AGUGGUUCU AACA UUCA CAGUU c u ||||| | | ||| ||||||||| ||||||||| |||| |||| ||||| | gcgac c g gcg gcggcccaG UCACCAGGA UUGU AAGU Guuaa g a a ag g c g A U A - c cg
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].
Genome context
chr14: 104117405-104117514 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-203a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-203a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-203a-3p
| Accession | MIMAT0000264 |
| Description | Homo sapiens hsa-miR-203a-3p mature miRNA |
| Sequence | 65 - GUGAAAUGUUUAGGACCACUAG - 86 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-203a-5p
| Accession | MIMAT0031890 |
| Description | Homo sapiens hsa-miR-203a-5p mature miRNA |
| Sequence | 27 - AGUGGUUCUUAACAGUUCAACAGUU - 51 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
|
