Stem-loop hsa-mir-203a

Accession

MI0000283

Symbol

HGNC: MIR203A

Description

Homo sapiens hsa-mir-203a precursor miRNA mir-203

Gene
family

RF00696; mir-203

Literature search

297 open access papers mention hsa-mir-203a
(2724 sentences)

Sequence

49458 reads, 280 reads per million, 126 experiments

guguuggggacucgcgcgcuggguccAGUGGUUCUUAACAGUUCAACAGUUcuguagcgcaauuGUGAAAUGUUUAGGACCACUAGacccggcgggcgcggcgacagcga
.(((((..(.(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).)..))))).

Structure

g     gg a u   g         c         U    G    A     - ug 
 uguug  g c cgc cgcuggguc AGUGGUUCU AACA UUCA CAGUU c  u
 |||||  | | ||| ||||||||| ||||||||| |||| |||| ||||| |   
 gcgac  c g gcg gcggcccaG UCACCAGGA UUGU AAGU Guuaa g  a
a     ag g c   g         A         U    A    -     c cg 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2].

Genome context

chr14: 104117405-104117514 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-203a

Disease association

hsa-mir-203a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-203a-3p

• Accession: MIMAT0000264
• Description: Homo sapiens hsa-miR-203a-3p mature miRNA
• Sequence: 65 - GUGAAAUGUUUAGGACCACUAG - 86
• Evidence: experimental ; cloned [2]

Mature hsa-miR-203a-5p

• Accession: MIMAT0031890
• Description: Homo sapiens hsa-miR-203a-5p mature miRNA
• Sequence: 27 - AGUGGUUCUUAACAGUUCAACAGUU - 51
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 17622355
   MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?
   Sonkoly E, Wei T, Janson PC, Sääf A, Lundeberg L, Tengvall-Linder M, Norstedt G, Alenius H, Homey B, Scheynius A, Ståhle M, Pivarcsi A
   PLoS One (2007) 2:e610