Accession
MI0000282
Symbol
HGNC:
MIR199B
Description
Homo sapiens
hsa-mir-199b precursor miRNA mir-199
Gene
family?
family?
RF00144;
mir-199
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR199B is a microRNA implicated in various biological processes and disease states. Overexpression of MIR199B does not significantly alter HIF-1α mRNA or NFκB mRNA and protein levels [PMC3645752]. The specific PCR primers for MIR199B have been designed to amplify a 66 bp product [PMC3645752]. MIR199B deficiency in a mouse model leads to increased levels of ACR, BUN, Cr, and proteinuria, suggesting that MIR199B has a protective role that is lost when it is absent [PMC8257373]. In the context of SARS-CoV-2 infection, MIR199B is one of the differentially expressed pri-miRNAs that show increased levels in patients' plasma [PMC9677482]. In breast cancer (BC), MIR199B has been reported as up-regulated [PMC3828615], and it has been studied for its potential role in VEGF transcriptional activation and secretion [PMC4737258]. The microRNA also plays a role in cancer biology by inhibiting the transcription factor HES1, which leads to reduced pluripotency in cancer stem cells and decreased growth of medulloblastoma [PMC3645752]. Furthermore, higher expression levels of MIR199B are associated with shorter progression-free survival (PFS) in patients with certain cancers [PMC6183594].
Literature search
143 open access papers mention hsa-mir-199b
(531 sentences)
(531 sentences)
Sequence
3258077
reads,
9807
reads per million, 155 experiments
ccagaggacaccuccacuccgucuaCCCAGUGUUUAGACUAUCUGUUCaggacucccaaauuguACAGUAGUCUGCACAUUGGUUAggcugggcuggguuagacccucgg
((.((((.....(((((((.(((((.(((((((.(((((((.((((.(((..........))).))))))))))).))))))).))))).))).))))......))))))
((.((((.....(((((((.(((((.(((((((.(((((((.((((.(((..........))).))))))))))).))))))).))))).))).))))......))))))
Structure
a -acacc - c C U U U gacu cc gagg ucca cuc gucua CCAGUGU UAGACUA CUGU Cag c || |||| |||| ||| ||||| ||||||| ||||||| |||| ||| gg cucc gggu ggg cggAU GGUUACA GUCUGAU GACA guu c - cagauu c u U C - u aaac
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised 5' miR has been validated in zebrafish, the ends mapped by cloning [2], and later verified in human [3].
Genome context
chr9: 128244721-128244830 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-199b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-199b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-199b-5p
| Accession | MIMAT0000263 |
| Description | Homo sapiens hsa-miR-199b-5p mature miRNA |
| Sequence | 26 - CCCAGUGUUUAGACUAUCUGUUC - 48 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-199b-3p
| Accession | MIMAT0004563 |
| Description | Homo sapiens hsa-miR-199b-3p mature miRNA |
| Sequence | 65 - ACAGUAGUCUGCACAUUGGUUA - 86 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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