Accession
MI0000274
Symbol
HGNC:
MIR187
Description
Homo sapiens
hsa-mir-187 precursor miRNA mir-187
Gene
family?
family?
RF00674;
mir-187
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR187 is a microRNA implicated in the regulation of immune responses and has been observed to modulate the potassium channel KCNK10/TREK-2 in a rat epilepsy model [PMC7041117]. It acts as a negative modulator of lipopolysaccharide (LPS) responses, directly limiting TNF-α production and reducing IL-6 and IL-12p40 transcription by targeting the transcription factor IkB [PMC5900789]. MIR187 is also part of a miRNA network driven by IL-10, which promotes anti-inflammatory responses while suppressing pro-inflammatory miRNAs [PMC5900789]. Upon LPS stimulation, IL-10 enhances miR146b and sustains MIR187 expression in myeloid cells, indicating its role in inflammatory regulation [PMC5900789]. In reproductive pathology, MIR187 has been identified as significantly overexpressed in the villus of women with recurrent pregnancy loss (RPL) [PMC5572592], and its expression is associated with immune infiltration levels in different immune-infiltrating groups [PMC7163112]. These findings suggest that MIR187 may serve as a potential biomarker for immune-related conditions and could be a target for therapeutic intervention to modulate inflammatory responses.
Literature search
52 open access papers mention hsa-mir-187
(335 sentences)
(335 sentences)
Sequence
9261
reads,
104
reads per million, 66 experiments
ggucgggcucaccaugacacagugugagaccucgGGCUACAACACAGGACCCGGGCgcugcucugaccccUCGUGUCUUGUGUUGCAGCCGGagggacgcagguccgca
.(.((((((.............((((...((((.((((.(((((((((((.((((.((......).).)).)).))))))))))).)))).))))..))))))))))).
.(.((((((.............((((...((((.((((.(((((((((((.((((.((......).).)).)).))))))))))).)))).))))..))))))))))).
Structure
g u caccaugacacag aga g A C - C - ug g cgggcu ugug ccuc GGCU CAACACAGGAC CG GG g c c | |||||| |||| |||| |||| ||||||||||| || || | | c gccugg acgc ggaG CCGA GUUGUGUUCUG GC cc c g u a - ------------- -ag G C U U c a uc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr18: 35904818-35904926 [-]
Disease association
hsa-mir-187 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-187-5p
| Accession | MIMAT0004561 |
| Description | Homo sapiens hsa-miR-187-5p mature miRNA |
| Sequence | 35 - GGCUACAACACAGGACCCGGGC - 56 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-187-3p
| Accession | MIMAT0000262 |
| Description | Homo sapiens hsa-miR-187-3p mature miRNA |
| Sequence | 71 - UCGUGUCUUGUGUUGCAGCCGG - 92 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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