miRBase entry: hsa-mir-187

Stem-loop hsa-mir-187

Homo sapiens hsa-mir-187 precursor miRNA
Gene family
MIPF0000078; mir-187

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR187 is a microRNA that is associated with the regulation of the potassium channel KCNK10/TREK-2 in a rat epilepsy model [PMC7041117]. It acts as a negative modulator of LPS responses by limiting TNF-α production and reducing IL-6 and IL-12p40 transcription [PMC5900789]. Through a complex network of miRNAs, MIR187 is upregulated by IL-10, which drives anti-inflammatory responses [PMC5900789]. In the context of recurrent pregnancy loss (RPL), MIR187 is significantly overexpressed in the villus of RPL women [PMC5572592]. It has also been identified as induced in RPL and suppressed in miR100, let7a, let7b, let7c, and miR21 [PMC4495342]. IL-10 has been shown to regulate the expression of MIR187 along with other miRNAs such as miR-155 and miR-146a/b [PMC5161420]. In immune infiltration studies, MIR187 expression levels were found to be highest in high-infiltrating groups compared to median-infiltrating and low-infiltrating groups [PMC7163112]. Additionally, MIR187 has been associated with immune responses along with other noncoding RNAs such as mir142, mir223, mir155, mir200a/b [PMC7163112]. Further research exploring the relationships between noncoding RNAs and immune responses is warranted [PMC7163112].

Literature search
52 open access papers mention hsa-mir-187
(335 sentences)


9261 reads, 104 reads per million, 66 experiments

g u      caccaugacacag    aga    g    A           C  -  C - ug 
 g cgggcu             ugug   ccuc GGCU CAACACAGGAC CG GG g c  c
 | ||||||             ||||   |||| |||| ||||||||||| || || | |   
 c gccugg             acgc   ggaG CCGA GUUGUGUUCUG GC cc c g  u
a -      -------------    -ag    G    C           U  U  c a uc 

Annotation confidence High
Do you think this miRNA is real?
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr18: 35904818-35904926 [-]

Disease association
hsa-mir-187 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-187-5p

Accession MIMAT0004561
Description Homo sapiens hsa-miR-187-5p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-187-3p

Accession MIMAT0000262
Description Homo sapiens hsa-miR-187-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540