Accession
MI0000273
Symbol
HGNC:
MIR183
Description
Homo sapiens
hsa-mir-183 precursor miRNA mir-183
Gene
family?
family?
RF00663;
mir-183
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR183 is a microRNA that has been studied in various biological contexts, including its role in ototoxicity and cancer metastasis [PMC6163699; PMC8074316].'>PMC8074316].. In a study involving mice, researchers compared the levels of MIR183 in the serum to its levels in the cochlea and kidney following ototoxicity using quantitative reverse transcription PCR (qRT-PCR) [PMC6163699]. Additionally, MIR183 has been implicated in human cancer, with a study on sporadic medullary thyroid carcinomas (MTCs) finding a close association between MIR183 expression and lymph node metastasis [PMC8074316]. These findings suggest that MIR183 may serve as a potential biomarker for both ototoxicity in mice and for the progression of certain human cancers [PMC6163699; PMC8074316]..
Literature search
202 open access papers mention hsa-mir-183
(1028 sentences)
(1028 sentences)
Sequence
98249
reads,
635
reads per million, 129 experiments
ccgcagagugugacuccuguucugugUAUGGCACUGGUAGAAUUCACUgugaacagucucagucaGUGAAUUACCGAAGGGCCAUAAacagagcagagacagauccacga
.((..((.(.((.(((.((((((((.((((((.((((((..(((((((((((......)))..))))))))))))..)).)))))).))))))))))).)).)))..)).
.((..((.(.((.(((.((((((((.((((((.((((((..(((((((((((......)))..))))))))))))..)).)))))).))))))))))).)).)))..)).
Structure
c ca g g a c g A -- GA -- ac cg ga u ug cuc uguucugu UAUGGC CU GGUA AUUCACUg uga a || || | || ||| |||||||| |||||| || |||| |||||||| ||| gc cu a ac gag acgagaca AUACCG GA CCAU UAAGUGac acu g a ac - g a - A G AG -- ug cu
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the 5' end mapped by PCR. Expression was later confirmed in human [2,3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr7: 129774905-129775014 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-183
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-183 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-183-5p
| Accession | MIMAT0000261 |
| Description | Homo sapiens hsa-miR-183-5p mature miRNA |
| Sequence | 27 - UAUGGCACUGGUAGAAUUCACU - 48 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-183-3p
| Accession | MIMAT0004560 |
| Description | Homo sapiens hsa-miR-183-3p mature miRNA |
| Sequence | 66 - GUGAAUUACCGAAGGGCCAUAA - 87 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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