Accession
MI0000269
Symbol
HGNC:
MIR181A2
Description
Homo sapiens
hsa-mir-181a-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR181A2, a microRNA, is transcribed from the MIR181A2HG host gene and is implicated in various cellular processes, including the modulation of cancer progression and glucose metabolism [PMC6781644], [PMC9430013]. Its transcription is influenced by a multitude of transcription factors and is associated with enhancer and promoter regions, making it a significant target for research [PMC8979821]. MIR181A2 overexpression has been observed to downregulate PCAF mRNA and protein levels, suggesting a regulatory role in gene expression [PMC5573355]. Furthermore, MIR181A2 downregulation has been linked to increased HIV transcription and infectivity of progeny virus, indicating its potential role in HIV latency and reactivation mechanisms [PMC5573355]. The interaction between HIV's Env glycoprotein and cellular receptors can lead to the downregulation of MIR181A2, which may facilitate viral LTR acetylation and transcription upon cessation of HAART treatment [PMC5573355]. The modulation of PCAF expression by MIR181A2 further underscores its regulatory capacity in cellular signaling pathways [PMC5573355], while its host gene MIR181A2HG's overexpression in certain tissues suggests additional layers of regulatory complexity yet to be fully understood [PMC6380385], [PMC7891834], [PMC10111190].
Literature search
487 open access papers mention hsa-mir-181a-2
(2580 sentences)
(2580 sentences)
Sequence
2190059
reads,
4211
reads per million, 140 experiments
agaagggcuaucaggccagccuucagaggacuccaaggAACAUUCAACGCUGUCGGUGAGUuugggauuugaaaaaACCACUGACCGUUGACUGUACCuugggguccuua
.((((((((....)))...))))).(((((((((((((.(((.((((((..(((((((.((((...........))))))))))))))))).))).))))))))))))).
.((((((((....)))...))))).(((((((((((((.(((.((((((..(((((((.((((...........))))))))))))))))).))).))))))))))))).
Structure
agaagggcuaucaggccagccuuca A U CU A ggga
gaggacuccaagg ACA UCAACG GUCGGUG GUuu u
||||||||||||| ||| |||||| ||||||| |||| u
uuccugggguuCC UGU AGUUGC CAGUCAC CAaa u
------------------------a A C -- - aaag
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. and Lui et al. later verify expression in human [4-5].
Genome context
chr9: 124692442-124692551 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-181a-2
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-181a-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-181a-5p
| Accession | MIMAT0000256 |
| Description | Homo sapiens hsa-miR-181a-5p mature miRNA |
| Sequence | 39 - AACAUUCAACGCUGUCGGUGAGU - 61 |
| Evidence |
experimental
cloned [2,4-6] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-181a-2-3p
| Accession | MIMAT0004558 |
| Description | Homo sapiens hsa-miR-181a-2-3p mature miRNA |
| Sequence | 77 - ACCACUGACCGUUGACUGUACC - 98 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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