Accession
MI0000268
Symbol
HGNC:
MIR34A
Description
Homo sapiens
hsa-mir-34a precursor miRNA mir-34
Gene
family?
family?
RF00456;
mir-34
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR34A is a microRNA implicated in various cellular processes and diseases, including cancer [PMC4650715]. In gastric cancer cell lines, BGC-823 showed a notable downregulation of MIR34A compared to the normal gastric epithelium [PMC4650715]. This microRNA is involved in the regulation of genes such as MYCN and ZNF281, and its downregulation is similar to the effects observed with c-Myc in colon carcinoma cells [PMC6048510]. MIR34A also plays a role in the immune system, where its upregulation may contribute to T cell activation and induction in autoimmune diseases [PMC5351619]. In addition, it has been observed that MIR34A can regulate gene expression post-transcriptionally by targeting Lef-1 with the help of miR-223 [PMC6282069]. The expression patterns of mature MIR34A are inversely related to those of pri-MIR34A when METTL3 expression is manipulated [PMC7347714]. Furthermore, disruptions involving both TP53 and MIR34A are associated with extremely poor survival outcomes in certain cancers [PMC4039115], while its overexpression has been linked to reduced dendrite outgrowth [PMC5928558]. Collectively, these findings underscore the multifaceted role of MIR34A as a critical regulator in both oncogenic processes and immune responses.
Literature search
927 open access papers mention hsa-mir-34a
(9143 sentences)
(9143 sentences)
Sequence
47919
reads,
442
reads per million, 147 experiments
ggccagcugugaguguuucuuUGGCAGUGUCUUAGCUGGUUGUugugagcaauaguaaggaagCAAUCAGCAAGUAUACUGCCCUagaagugcugcacguuguggggccc
((((.(((((((((((((((..(((((((((((.((((((((((....((....)).....))))))))))))).))))))))..))))))))).))))..))..)))).
((((.(((((((((((((((..(((((((((((.((((((((((....((....)).....))))))))))))).))))))))..))))))))).))))..))..)))).
Structure
- -a -- - uU - A -guga a ggcc gc ugug aguguuucu GGCAGUGU CUU GCUGGUUGUu gc a |||| || |||| ||||||||| |||||||| ||| |||||||||| || ccgg ug gcac ucgugaaga CCGUCAUA GAA CGACUAACga ug u c gg uu g UC U - aggaa a
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Dostie et al. independently cloned this sequence in human but misnamed the sequence miR-172 (the sequence is unrelated to MIR172 from Arabidopsis) [2]. The sequence maps to human chromosome 1. Human miR-34a was previously named miR-34 here and in [1], but is renamed to clarify homology with the alternatively named mouse sequence (MIR:MI0000584). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr1: 9151668-9151777 [-]
Disease association
hsa-mir-34a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-34a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-34a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-34a-5p
| Accession | MIMAT0000255 |
| Description | Homo sapiens hsa-miR-34a-5p mature miRNA |
| Sequence | 22 - UGGCAGUGUCUUAGCUGGUUGU - 43 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-34a-3p
| Accession | MIMAT0004557 |
| Description | Homo sapiens hsa-miR-34a-3p mature miRNA |
| Sequence | 64 - CAAUCAGCAAGUAUACUGCCCU - 85 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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