Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR10B is a miRNA that is upregulated in both KO and KI mice and negatively regulates spermatid differentiation [PMC10001410]. Mim23-expressing cells show upregulation of tumorigenic miR10a and MIR10B, as well as downregulation of antiproliferative miR129-5p, which is predicted to alter cell growth and invasion properties [PMC3892995].
cca guaa u A G C u g c
gagguu cguug cuauauaU CCCU UAGAA CGAAUUUGUG g uau c
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cuucaa guagc gguauaUA GGGG AUCUU GCUUAGACAc u aua g
--a aaac u A - A - g u
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This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences . Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Michael et al. subsequently verified expression of miR-10b in human . The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .