Stem-loop hsa-mir-10a

Accession

MI0000266

Symbol

HGNC: MIR10A

Description

Homo sapiens hsa-mir-10a precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR10A is a microRNA implicated in the regulation of gene expression and has been observed to influence the metastatic potential of cervical cancer cells by targeting the tumor suppressor gene PTEN [PMC6398879]. Additionally, MIR10A has been reported to interact with the 5' untranslated regions (UTRs) of mRNAs, particularly those with a terminal oligopyrimidine (TOP) motif, which can lead to both repression and activation of translation, suggesting a complex role in post-transcriptional regulation [PMC1794424]. Research findings have also indicated an upregulation of MIR10A in certain contexts, while other microRNAs did not exhibit significant changes in expression levels [PMC6132736].

Literature search

272 open access papers mention hsa-mir-10a
(1858 sentences)

Sequence

1320573 reads, 4312 reads per million, 130 experiments

gaucugucugucuucuguauaUACCCUGUAGAUCCGAAUUUGUGuaaggaauuuuguggucaCAAAUUCGUAUCUAGGGGAAUAuguaguugacauaaacacuccgcucu
....(((.((((..((((((((.((((.(((((.((((((((((................)))))))))).))))))))).))))))))..))))...))).........

Structure

-----gauc   --c    uu        A    G     C          uaaggaa 
         ugu   uguc  cuguauaU CCCU UAGAU CGAAUUUGUG       u
         |||   ||||  |||||||| |||| ||||| ||||||||||        
         aca   acag  gauguAUA GGGG AUCUA GCUUAAACac       u
ucucgccuc   aau    uu        A    -     U          ugguguu 

Annotation confidence High

Comments

This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Mature products were later verified in human [2].

Genome context

chr17: 48579838-48579947 [-]

Disease association

hsa-mir-10a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-10a-5p

• Accession: MIMAT0000253
• Description: Homo sapiens hsa-miR-10a-5p mature miRNA
• Sequence: 22 - UACCCUGUAGAUCCGAAUUUGUG - 44
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-10a-3p

• Accession: MIMAT0004555
• Description: Homo sapiens hsa-miR-10a-3p mature miRNA
• Sequence: 63 - CAAAUUCGUAUCUAGGGGAAUA - 84
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540