Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR10A, a microRNA, has been demonstrated to enhance the metastatic potential of cervical cancer cells by targeting PTEN, as shown in a study by Zeng et al [PMC6398879]. Ulf Ørom, from the University of Copenhagen, reported that MIR10A can interact with the 5' UTR of mRNAs harboring the TOP regulatory motif and can have both negative and positive impacts on their translation [PMC1794424]. In a separate study, it was found that MIR10A exhibited an increase in expression, while other tested miRNAs did not show significant changes [PMC6132736].
-----gauc --c uu A G C uaaggaa
ugu uguc cuguauaU CCCU UAGAU CGAAUUUGUG u
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aca acag gauguAUA GGGG AUCUA GCUUAAACac u
ucucgccuc aau uu A - U ugguguu
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This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences . Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Mature products were later verified in human .